Abstracts
Objective: To investigate the expression of PTEN in endometrial carcinoma and its clinical significance. Methods: Reverse transcriptase-polymerase chain reaction and Western-blot methods were used to detect PTEN expression in 28 cases of endometrial carcinoma. Results: mRNA and protein expression levels of PTEN in endometrial carcinomas were significantly lower than those in normal endometrium (P<0.01). Conclusion: PTEN may play an important role in the tumorigenesis of endometrial carcinoma.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Mutter GL, Lin MC, Fitzgerald JT, et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers [J]. J Natl Cancer Inst 2000; 92:924–30.
Munoz J, Lazcoz P, Inda MM. Homozygous deletion and expression of PTEN and DMBT1 in human primary neuroblastoma and cell lines [J]. Int J Cancer 2004; 109:673–9.
Stambolic V, Tsao MS, Macpherson D. High Incidence of breast and endometrial neoplasia resembling human cowden syndrome in pten+/− mce [J]. Cancer Research 2000; 60:3605–11
Di Cristofano A, Pandolfi PP. The multiple roles of PTEN in tumor suppression [J]. Cell 2000; 100:387–90
Weng L, Brown J, Eng C. PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways [J]. Hum Mol Genet 2001; 10:237–42
Kurose K, Zhou XP, Araki T, et al. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas [J]. Am J Pathol 2001; 158:2097–106
Weng LP, Smith WM, Brown JL, et al. PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model [J]. Hum Mol Genet 2001; 10:605–16
Elit L, Hirte H. Novel strategies for systemic treatment of endometrial cancer [J]. Expert Opin Investig Drugs 2000; 9:2831–53
MacDonald ND, Salvesen HB, Ryan A, et al. Frequency and prognostic impact of microsatellite instability in a larger population-based study of endometrial carcinomas [J]. Cancer Res 2000; 60:1750–2
Mutter GL, Lin MC, Fitzgerald JT, et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers [J]. J Natl Cancer Inst 2000; 92:924–30
Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer [J]. Science 1997; 275:1943–7
Marsh D. J, Dahia P. L, Caron S, et al. Germline PTEN mutations in Cowden syndrome-like families [J]. J Med Genet 1998; 35:881–5
Parsons R. Human cancer, PTEN and the PI-3 kinase pathway [J]. Semin Cell Dev Biol 2004; 15:171–6.
Raftopoulou M, Etienne-Manneville S, Self A, et al. Regulation of cell migration by the C2 domain of the tumor suppressor PTEN [J]. Science 2004; 303:1179–81.
Chen Y, Zheng H, Yang X, et al. Effects of mutation and expression of PTEN gene mRNA on tumorigenesis andprogression of epithelial ovarian cancer [J]. Chin Med Sci J 2004; 19:25–30.
Minaguchi T, Yoshikawa H, Oda K. PTEN Mutation located only outside exons 5, 6, and 7 is an independent predictor of favorable survival in endometrial carcinomas [J]. Clin Cancer Res 2001; 7:2636–42.
Author information
Authors and Affiliations
Corresponding author
Additional information
Biography: GE Xiu-jun (1972–), female, master of medicine, Guangdong College of Pharmacy, majors in obstetrics and gynecology.
Rights and permissions
About this article
Cite this article
Ge, Xj., Liu, Zh., Li, Yy. et al. Expression and significance of PTEN in endometrial carcinoma. Chin. J. Cancer Res. 17, 53–56 (2005). https://doi.org/10.1007/s11670-005-0011-8
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s11670-005-0011-8