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X-ray repair cross-complementing group 1 (XRCC1) Arg 399 Gln polymorphism and aflatoxin B1 (AFB1)-related hepatocellular carcinoma (HCC) in Guangxi population

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Chinese Journal of Cancer Research

Abstract

Objective: To explore the relationship of XRCC1 Arg 399 Gln polymorphism and AFB1-related hepatocellular carcinoma (HCC) risk in Guangxi population. Methods: The DNA samples from peripheral blood white blood cells were obtained from subjects including 140 HCC and 536 controls. The XRCC1 gene 399 codon polymorphism was detected by PCR-RFLP technique. Results: The frequency of XRCC1 399 Arg/Gln & Gln/Gln genotype in HCC patients (48.57%) was significantly higher that in normal controls (32.46%), and XRCC1 399 Arg/Gln & Gln/Gln genotype was associated with increased risk of HCC (adjusted odds ratios (OR)=2.18, 95% confidence interval (CI) 1.27∼3.74). In addition, in the cohort of low/median level of AFB1 exposure, the codon 399 Gln allele was associated with a conspicuous significantly increasing risk for HCC (adjusted OR=2.06, 95% CI=1.01∼4.20). Conclusion: The results indicate that the XRCC1 399 Gln allele is a potentially important determinant of susceptibility to AFB1-related HCC.

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Authors and Affiliations

  1. Department of Pathology, Guangxi Medical University, 530021, Nanning

    Long Xi-dai, Ma Yun, Wei Yi-ping & Deng Zhuo-lin

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  1. Long Xi-dai
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  2. Ma Yun
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  3. Wei Yi-ping
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  4. Deng Zhuo-lin
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Corresponding author

Correspondence to Ma Yun.

Additional information

Foundation item: This work was supported by the National Natural Science Foundation of China (No. 39860032).

Biography: LONG Xi-dai (1973–), male, master of medicine, Guangxi Medical University, majors in tumor pathology.

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Long, Xd., Ma, Y., Wei, Yp. et al. X-ray repair cross-complementing group 1 (XRCC1) Arg 399 Gln polymorphism and aflatoxin B1 (AFB1)-related hepatocellular carcinoma (HCC) in Guangxi population. Chin. J. Cancer Res. 17, 17–21 (2005). https://doi.org/10.1007/s11670-005-0004-7

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  • DOI: https://doi.org/10.1007/s11670-005-0004-7

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