Skip to main content
Log in

Cox multivariate regression analysis of recurrence factors for colonic carcinoma

  • Articles
  • Published:
Chinese Journal of Cancer Research

Abstract

Objective: To determine the independent prognostic factors in the recurrence of colonic carcinoma after curative resection. Methods: Two hundred and one patients undergoing curative resections for colonic carcinoma were investigated by univariate and Cox multivariate regression analyses. Ten factors contributed to the rate were analyzed. Results: Dukes stages, obstruction, postoperative chemotherapy as well as the growth manner of the tumor were significantly associated with the recurrence rate of colonic carcinoma (P<0.05) by univariate analysis, while Dukes stages, obstruction, and postoperative chemotherapy were significant factors by the multivariate analysis. Conclusion: Dukes stages, obstruction, and postoperative chemotherapy are independent prognostic factors in the recurrence of colonic carcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Platell C, Lim D, Tajudeen N, et al. Dose surgical sub-specialization influence survival in patients with colorectal cancer[J]? World J Gastroenterol 2003;9:961–4.

    PubMed  Google Scholar 

  2. Sibbering D, Locker A, Hardcastle J, et al. Blood transfusion and survival in colorectal cancer[J]. Dis Colon Rectum 1994; 37: 358–63.

    Article  PubMed  CAS  Google Scholar 

  3. Leite J, Granjo M, Martins M, et al. Effect of perioperative blood transfusions on survival of patients after radical surgery for colorectal cancer[J]. Int J Colorectal Dis 1993;8:129–33.

    Article  PubMed  CAS  Google Scholar 

  4. PonzdeLeon M, Sant M, Micheli A et al. Clinical and pathologic prognostic indicators in colorectal cancer: a population based study[J]. Cancer 1992; 69: 626–35.

    Article  CAS  Google Scholar 

  5. Smothers L, Hynan L, Fleming J, et al. Emergency surgery for colon carcinoma[J]. Dis Colon Rectum 2003;46:24–30.

    Article  PubMed  Google Scholar 

  6. Moertel CG, Fleming TR, Macdonald JS et al. Fluorouracil plus levamisole as effective adjuvant therapy after resectionof stage III colon carcinoma: a final report [J]. Ann Intern Med 1995; 122: 321–6.

    PubMed  CAS  Google Scholar 

  7. Demols A, Van Laethem JL. Adjuvant chemotherapy for colorectal cancer[J]. Curr Gastroenterol Rep 2002;4:420–6.

    Article  PubMed  Google Scholar 

  8. Kennedy AS, Harrison GH, Mansfield CM, et al. Survival of colorectal cancer cell lines treated with paclitaxel, radiation and 5-FU: effect of TP53 or hMLH1 deficiency[J]. Int J Cancer 2000; 90: 175–85.

    Article  PubMed  CAS  Google Scholar 

  9. Chester JD, Dent JT, Wilson G, et al. Protracted infusional 5-fluorouracil (5-FU) with bolus mitomycin in 5-FU-resistant colorectal cancer[J]. Ann Oncol 2000; 11: 235–7.

    Article  PubMed  CAS  Google Scholar 

  10. De Gramont A, Vignoud J, Tournigand C, et al. Oxaliplatin with high doseleucovorin and 5 fluorouracil 48 hour continuous infusion in pretreated metastatic colorectal cancer[J]. Eur J Cancer 1997;33:214–9.

    Article  PubMed  Google Scholar 

  11. Chen XX, Lai MD, Zhang YL, et al. Less cytotoxicity to combination therapy of 5-fluorouracil and cisplatin than 5-fluorouracil alone in human colon cancer cell lines[J]. World J Gastroenterol 2002; 8: 841–6.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Du Han-song.

Additional information

Foundation item: This work was supported by a grant from the Hubei Province Natural Science Foundation of China (No.2003 ABA151)

Biography: DU Han-song(1957–), male, doctor of medicine, Cancer Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, majors in etiology and epidemiology of cancer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Du, Hs., Wang, Gb., Qin, Qp. et al. Cox multivariate regression analysis of recurrence factors for colonic carcinoma. Chin. J. Cancer Res. 16, 274–278 (2004). https://doi.org/10.1007/s11670-004-0042-6

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11670-004-0042-6

Key words

CLC number

Navigation