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Expression of P120ctn in non-small-cell lung cancer: A clinicopathological study

  • Published:
Chinese Journal of Cancer Research

Abstract

Objective: To investigate the expression of p120ctn in non-small-cell lung cancer (NSCLC) and its relationship with clinicopathological factors and prognosis. Methods: p120ctn expression was tested by immunohistochemistry for 80 tumors from patients with non-small-cell lung cancer. Correlations were investigated between p120ctn immunostaining in primary tumors and clinicopathological characteristics and survival. Results: Abnormal expression of p120ctn was found in 68/80(85%) tumors in which 43 cases had cytoplasmic staining. Abnormal staining of p120ctn was related with high TNM stage (P=0.003) and nodal metastasis (P=0.024). However, there was no correlation between altered expression with poor differentiation and histological type. According to Kaplan-Meier survival estimate, the expression of p120ctn was related to the poor survival (P=0.015) of patients. A Cox regression analysis revealed that p120ctn expression was a significant independent factor in the prediction of survival for patients with non-small-cell lung cancer (P=0.008). Conclusion: altered expression of p120ctn was found in non-small-cell lung cancers and was correlated with lymph node metastasis and prognosis. From a practical point of view, the expression of p120ctn can be of prognostic value for patients with non-small-cell lung cancer.

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Authors and Affiliations

  1. Department of Pathology, College of Basic Medical Sciences, China Medical University, 110001, Shenyang

    Zhang Zhi-kun, Lin Dong & Wang En-hua

  2. Department of Biochemistry, College of Basic Medical Sciences, China Medical University, 110001, Shenyang

    Guan Yi

Authors
  1. Zhang Zhi-kun
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  2. Lin Dong
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  3. Wang En-hua
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  4. Guan Yi
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Corresponding author

Correspondence to Wang En-hua.

Additional information

Foundation items: This work was supported by a grant from the Scientific Research Foundation of the Ministry of Education of PR China (No. 2002-247).

Biography: Zhang Zhi-kun(1982–), male, candidate for Ph.D. degree of pathology, China Medical University, majors in molecular pathology of tumor.

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Zhang, Zk., Lin, D., Wang, Eh. et al. Expression of P120ctn in non-small-cell lung cancer: A clinicopathological study. Chin. J. Cancer Res. 14, 274–278 (2002). https://doi.org/10.1007/s11670-002-0060-1

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  • DOI: https://doi.org/10.1007/s11670-002-0060-1

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