Abstract
Objective: To investigate the expression of survivin gene and its significance in acute leukemia. Methods: The expression of surviving in 134 acute leukemia patients and 4 leukemia cell lines was detected by RT-PCR and immunofluorescence analysis. Results: We detected survivin expression in 78 of 134 acute leukemia patients and all the cell lines but not in normal controls and anemia patients. Survivin gene expression correlated with a lower white blood cell count, which was 11×109/L and 48×109/L in the positive and negative group respectively (P<0.01 by the Mann-Whitney test). In 55 cases of FAB M1/M2/M3, it was associated with leukemic cell maturation(P<0.01 by the Fisher test). Survivin expression was strongly related to survival time of acute leukemia patients (P<0.05). Conclusion: These data suggest that survivin expression may be considered as a new unfavorable prognostic factor for acute leukemia due to its important role in apoptosis inhibition that influences disease outcome.
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Foundation item: This work was supported by a grant from the National Natural Science foundation of China (No. 39970693).
Biography: Wang Xiao-juan(1972–), female, doctor of medicine, lecturer, Tongji Medical college, Huazhong University of Science & Technology, majors in immunology.
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Wang, Xj., Dai, Gy., Cao, Lm. et al. Prognostic significance of expression of survivin in acute leukemia. Chin. J. Cancer Res. 14, 265–269 (2002). https://doi.org/10.1007/s11670-002-0058-8
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DOI: https://doi.org/10.1007/s11670-002-0058-8