Abstract
Objective: To explore the expression of vascular endothelial growth factor(VEGF) and basic fibroblast growth factor(bFGF) in non-small cell lung cancer(NSCLC) and theIR clinical significance. Methods: The expression of VEGF and bFGF was examined at the protein levels by immunohistochemical staining in 96 NSCLC patients, and in 36 of which at the mRNA levels by reverse transcription-PCR analysis. Results: VEGF mRNAs were expressed predominately as its secretory forms (VEGF121 and VEGF165) in NSCLC tissues. The positive ratios of VEGF121 and VEGF165 were 69.5%(25 of 36) and 41.7%(15 of 36) respectively. The positive ratio of bFGF was 52.8(19 of 36) in the same tumor specimens. The positive ratios of VEGF and bFGF at protein levels were 55.55%(20 of 36) and 58.33%(21 of 36) respectively. A significant positive correlation was observed between VEGF and bFGF expression in NSCLC tissues(P=0.002). No significant interrelationship between VEGF, bFGF expression and clinical data(age, sex, histological subtype differentiation, P-stage, metastasis and survival) was found. Conclusions: VEGF and bFGF may play an important role in angiogenesis and act in a synergistic manner in NSCLC.
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Foundation item: This work was supported by a grant from the Beijing Natural Science Foundation (No.7992005) and from plan of new star of science and technology of Beijing(No. 99–148).
Biography: Zhang Wei(1964–), male, doctor of medicine, associate professor, now address: Center Hospital of Tai-an City, Shangdong Province, majors in chemotherapy of cancer.
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Zhang, W., Wang, J., Liu, X. et al. Expression of vascular endothelial growth factor and basic fibroblast growth factor in human non-small cell lung cancer and their clinical significance. Chin. J. Cancer Res. 14, 259–264 (2002). https://doi.org/10.1007/s11670-002-0057-9
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DOI: https://doi.org/10.1007/s11670-002-0057-9
Key word
- Non-small cell lung cancer
- Vascular endothelial growth factor(VEGF)
- Basic fibroblast growth factor(bFGF)