Abstract
Objective: To investigate the significance of E-cadherin (E-cad) and CD44v6 expression in human hepatocellular carcinomas (HCCs). Methods: An immunohistochemical method was used to detect E-cad and CD44v6 expression in 66 cases of HCCs. Results: The positive rates of E-cad and CD44v6 expression in human HCCs were 42.4%(28/66) and 39.4%(26/66), respectively. There was an inverse correlation between E-cad expression and invasive and metastatic potential of HCCs (P<0.01), and a positive correlation between the CD44v6 expression and invasive and metastatic potential of HCCs (P<0.01). Moreover, the 5-year survival rate in the E-cad-positive group was higher than in E-cad-negative group (P<0.01), and that in the CD44v6-positive group was lower than in the CD44v6-negative expression group (P<0.05). Conclusion: these data show a possible association between E-cad and CD44v6 expression and the potential of invasion and metastasis in HCCs. E-cad and CD44v6 expression may be used as an auxiliary prognostic indicator in HCCs.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ghadimi BM, Behrens J, Hoffmann I, et al. Immunohistological analysis of E-cadherin, alpha-, beta-and gamma-catenin expression in colorectal cancer: implications for cell adhesion and signaling[J]. Eur J Cancer 1999; 35:60.
Ramasami S, Kerr MK, Chapman AD, et al. Expression of Cd44v6 but not E-cadherin or β-catenin influences prognosis in primary pulmonary adenocarcinoma[J]. J Pathol 2000; 192:427.
Bankfalvi A, Terpe HJ, Breukelmann D, et al. Immunophenotypic and prognostic analysis of E-cardherin and β-catenin expression during breast carcinogenesis and tumor progression: a comparative study with CD44[J]. Histopathol 1999; 34:25.
Friedrichs K, Franke F, Lisboa BW, et al. CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancer[J]. Cancer Res 1995; 55:5424.
Osada T, Sakamoto M, Ino Y, et al. E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma[J]. Hepatol 1996; 24:1460.
Mathew J, Hines JE, Obafunwa JO, et al. CD44 is expressed in hepatocellular carcinomas showing vascular invasion[J]. J Pathol 1996; 179:74.
Washington K, Telen MJ, Gottfried MR, et al. Expression of cell adhesion molecule CD44 in primary tumors of the liver: an immunohistochemical study[J]. Liver 1997; 17:17.
Yamaguchi A. Expression of variant Cd44 in colorectal cancer and its relationship to liver metastasis[J]. Nippon Geka Gakkai Zasshi 1998; 99:409.
Terris B, Laurent PP, Belghitti J, et al. Prognostic influence of clinicopathologic features, DNA-ploidy, CD44v and p53 Expression in a large series of resected hepatocellular carcinoma in France[J]. Int J Cancer 1997; 74:614.
Gan Xiu-yun, Lao Shu-zhen, Yong Ling. Considered that CD44 expression of majority of tumor is in relationship to tumor metastasis, especially, variant type CD44, but not absolutely[J]. Chin Oncol 1998; 8: 267.
Author information
Authors and Affiliations
Corresponding author
Additional information
Foundation item: This work was supported by the National Natural Science Foundation of China (No. 3880388).
Biography: Zheng Jian-ming(1962–), master of medicine, attending physician, Secondary Military Medical University, majors in pathology.
Rights and permissions
About this article
Cite this article
Zheng, Jm., Zheng, Wq., Gong, Zj. et al. E-cadherin and CD44V6 expresion in human hepatocellular carcinomas. Chin. J. Cancer Res. 13, 284–287 (2001). https://doi.org/10.1007/s11670-001-0049-1
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s11670-001-0049-1