Abstract
Objective: To investigate the expression of Fas ligand in human colon carcinoma cell lines. Methods: A total of six human colon cancer cell lines were examined for the expression of Fas ligand mRNA and cell surface protein by using RT-PCR and flow cytometry respectively. Results: The results showed that Fas ligand mRNA was expressed in all of the six cancer cell lines and Fas ligand cell surface protein was expressed in part of them. Conclusion: These data suggest that Fas ligand was expressed, at least in part, in human colon cancer cell lines and might facilitate to escape from immune surveillance of the host.
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Foundation item: This work was supported by the National Natural Science Foundation of China (No. 39900143)
Biography: ZHANG Jian-jun(1971–), associate professor, Department of General Surgery, No. 150 Hospital of PLA, majors in oncology and surgery. Now works at Department of General Surgery, Changzheng Hospital, Second Military Medical University as a doctoral candidate.
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Zhang, Jj., Ding, Ex., Wang, Q. et al. Expression of fas ligand in human colon cancer cell lines. Chin. J. Cancer Res. 13, 262–264 (2001). https://doi.org/10.1007/s11670-001-0044-6
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DOI: https://doi.org/10.1007/s11670-001-0044-6