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Synergistic efficacy of adenovirus-mediated BCL-XS gene transfer and topotecan in ovarian cancer cell

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Chinese Journal of Cancer Research

Abstract

Objective: To observe the synergistic efficacy between Adenovirus-mediated bcl-Xs(Adv-bcl-Xs) gene transfer and chemotherapy on ovarian cancer cell growth. Methods: NuTu-19 cells were infected by different titers of Adv-bcl-Xs and treated with topotecan in the meantime. Cell proliferation was measured 3 days later by MTT. Graphical representations and statistical analyses for their interaction in tumor cells were done. Results: The statistical result and Graphical representations of the statistical modeling showed synergy effect on cell growth inhibition (P<0.01). Conclusion: There were synergistic efficacies between Adv-bcl-Xs gene therapy and Topotecan in ovarian cancer cell growth.

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Authors and Affiliations

  1. West China Second Hospital, Sichuan University, 610041, Chengdu, China

    Wang He

  2. University of Michigan Comprehensive Cancer Center, 48109-0724, MI, USA

    Vicki V Baker

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  1. Wang He
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  2. Vicki V Baker
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Correspondence to Wang He.

Additional information

Foundation item: This work was supported by a grant from the Science Foundation of National Committee of Education of China (No. 96361017).

Biography: WANG He (1953–), professor, West China Second Hospital, Sichuan University, majors in Gynecology.

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Wang, H., Baker, V.V. Synergistic efficacy of adenovirus-mediated BCL-XS gene transfer and topotecan in ovarian cancer cell. Chin. J. Cancer Res. 13, 254–257 (2001). https://doi.org/10.1007/s11670-001-0042-8

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  • DOI: https://doi.org/10.1007/s11670-001-0042-8

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