Abstract
Objective: To investigate cyclooxygenase- 2(Cox-2) protein expression in esophageal cancer and precancerous lesions. Methods: One hundred twenty biopsy specimens from esophageal carcinoma and 113 from patients with esophageal premalingnant lesions, 27 from individuals with normal esophageal mucosa and 3 from Barrett’s esophagus were examined for Cox-2 protein expression by immunohistochemistry. Results: Cox-2 protein was not observed in normal esophageal squamous and glandular epithelium, hyperplasia from mild to severe dysplasia lesions and carcinoma in situ. Positive Cox-2 protein expression was found in 4 of 60 specimens of invasive squamous-cell carcinomas, 21 of 30 specimens of esophageal adenocarcinomas and in 3 of 3 Barret’s esophageal tissues. Conclusion: The Cox-2 protein expression may be associated with the development of the esophageal adenocarcinomas but not esophageal squamous-cell carcinomas.
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Foundation item: This work was supported by a grant from the National 9th Five-Year Program of China (No. 96-906-01-02) and the National Natural Science Foundation of China (No. 39870838).
Biography: WANG Li-feng(1969–), doctor of medicine, attending physician, works at the First Hospital, Harbin Medical University, majors in pathology.
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Wang, Lf., Zhang, W., Wang, Wr. et al. A study on cyclooxygenase -2 protein expression in esophageal caiconogenesis. Chin. J. Cancer Res. 13, 251–253 (2001). https://doi.org/10.1007/s11670-001-0041-9
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DOI: https://doi.org/10.1007/s11670-001-0041-9