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Effect of TiO2 Nanofiller Concentration on the Mechanical, Thermal and Biological Properties of HDPE/TiO2 Nanocomposites

  • Mohammad Sayem Mozumder
  • Abdel-Hamid I. Mourad
  • Anusha Mairpady
  • Hifsa Pervez
  • Md Emdadul Haque
Article

Abstract

The necessity for advanced and effective biomimetic tissue engineering materials has increased massively as bone diseases such as osteoporosis and bone cancer have become a major public health problem. Therefore, the objective of this study is to develop titanium dioxide (TiO2) nanoparticles-enriched high-density polyethylene (HDPE) nanocomposites that could serve as potential biomaterials. HDPE/TiO2 nanocomposites with varying TiO2 nanoparticles content were fabricated by using injection molding technique and were subjected to mechanical, thermal and biological characterization. SEM–EDS analysis confirmed even dispersion of TiO2 nanoparticles into the HDPE matrix. It was observed from the mechanical testing that the addition of TiO2 nanoparticles to HDPE noticeably improved the stiffness (from 345 to 378 MPa) while maintaining almost similar yield strength of pure HDPE. The thermal analyses revealed that TiO2 nanoparticles inclusion to HDPE matrix enhanced the thermal stability of nanocomposites, as the overall rate of crystallization increased by almost 4%. Furthermore, biocompatibility of nanocomposites was also studied by means of various cell culture experiments; human osteoblasts (hFOB) were seeded on the HDPE/TiO2 nanocomposites and were visualized through SEM after 72 h of incubation; surface morphology revealed normal cell growth and spreading with more attachment on PNC-10 that contains 10 wt.% of TiO2. Moreover, cell viability assays (i.e., MTT and cell attachment) revealed consistent increase in cell count and metabolic activity when triplicate cultures were incubated for 1, 3 and 7 days.

Keywords

biocompatibility cell attachment crystallinity HDPE/TiO2 nanocomposites human osteoblasts nanofillers proliferation stiffness yield strength 

Notes

Acknowledgments

Authors like to acknowledge UPAR (UAEU-NRF) research grant to carry out this research. Authors would also like to thank Eng. Abdul Sattar, Dr. Saeed Tariq and Mr. Uma Maheswara Kannuri for their help in the experimental work.

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© ASM International 2018

Authors and Affiliations

  • Mohammad Sayem Mozumder
    • 1
  • Abdel-Hamid I. Mourad
    • 2
  • Anusha Mairpady
    • 1
  • Hifsa Pervez
    • 1
  • Md Emdadul Haque
    • 3
  1. 1.Department of Chemical and Petroleum EngineeringUAE University, PO Box 15551Al AinUAE
  2. 2.Department of Mechanical EngineeringUAE UniversityAl AinUAE
  3. 3.Biochemistry, College of Medicine and Health SciencesUAE UniversityAl AinUAE

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