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Journal of Electronic Materials

, Volume 45, Issue 5, pp 2563–2568 | Cite as

Surface-Enhanced Raman Spectroscopy Study of 4-ATP on Gold Nanoparticles for Basal Cell Carcinoma Fingerprint Detection

  • Luu Manh Quynh
  • Nguyen Hoang Nam
  • K. Kong
  • Nguyen Thi Nhung
  • I. Notingher
  • M. Henini
  • Nguyen Hoang Luong
Article

Abstract

The surface-enhanced Raman signals of 4-aminothiophenol (4-ATP) attached to the surface of colloidal gold nanoparticles with size distribution of 2 to 5 nm were used as a labeling agent to detect basal cell carcinoma (BCC) of the skin. The enhanced Raman band at 1075 cm−1 corresponding to the C-S stretching vibration in 4-ATP was observed during attachment to the surface of the gold nanoparticles. The frequency and intensity of this band did not change when the colloids were conjugated with BerEP4 antibody, which specifically binds to BCC. We show the feasibility of imaging BCC by surface-enhanced Raman spectroscopy, scanning the 1075 cm−1 band to detect the distribution of 4-ATP-coated gold nanoparticles attached to skin tissue ex vivo.

Keywords

Skin cancer basal cell carcinoma surface-enhanced Raman scattering gold nanoparticles 

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Copyright information

© The Minerals, Metals & Materials Society 2016

Authors and Affiliations

  • Luu Manh Quynh
    • 1
  • Nguyen Hoang Nam
    • 1
    • 2
  • K. Kong
    • 3
  • Nguyen Thi Nhung
    • 1
  • I. Notingher
    • 3
  • M. Henini
    • 3
  • Nguyen Hoang Luong
    • 2
  1. 1.Faculty of Physics, Hanoi University of ScienceVietnam National University, HanoiHanoiVietnam
  2. 2.Nano and Energy Center, Hanoi University of ScienceVietnam National University, HanoiHanoiVietnam
  3. 3.School of Physics and AstronomyNottingham UniversityNottinghamUK

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