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Conjugation of TbPO4·H2O-Based Nanowires with Immunoglobulin G for Bioimaging

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Abstract

The surface modification, functionalization, and conjugation of undoped and 11 at.% Eu3+-doped TbPO4 ·H2O nanowires by using silica, a thyocyanate functional group, and immunoglobulin G, respectively, are described in this paper. For the core layer of obtained conjugated nanowires, the undoped TbPO4 ·H2O exhibited characteristic photoluminescent green emission corresponding to 5 D 4 → 7 F J transitions (J = 6, 5, 4, 3) while the incorporation of Eu3+ into TbPO4 ·H2O lattice was evidenced by Starks splitting transitions at 590, 615, 693 nm of Eu3+ ions for the case of 11 at.% Eu3+-doped TbPO4 ·H2O. The results also indicated that both immunoglobulin G-conjugated undoped and Eu3+-doped TbPO4 ·H2O nanowires can be used in the fluorescent immune analysis as a biomedical label maker to identify measles viruses in vaccine testing.

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Acknowledgements

This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant Number 103.06-2010.16. The authors are also thankful to the Key Laboratory of Electronic Materials and Devices, Institute of Materials Science, Vietnam Academy of Science and Technology.

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Authors and Affiliations

  1. Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam

    Nguyen Thanh Huong, Pham Thi Lien, Nguyen Manh Hung, Nguyen Duc Van, Nguyen Thanh Binh & Le Quoc Minh

  2. Hanoi University of Science and Technology, 1 Dai Co Viet Road, Hanoi, Vietnam

    Tran Thi Thuy

  3. Duy Tan University, 14/25 Quang Trung, Da Nang, Vietnam

    Le Quoc Minh

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  1. Nguyen Thanh Huong
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  2. Pham Thi Lien
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  3. Nguyen Manh Hung
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  4. Nguyen Duc Van
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  5. Tran Thi Thuy
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  6. Nguyen Thanh Binh
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  7. Le Quoc Minh
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Correspondence to Nguyen Thanh Huong.

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Huong, N.T., Lien, P.T., Hung, N.M. et al. Conjugation of TbPO4·H2O-Based Nanowires with Immunoglobulin G for Bioimaging. J. Electron. Mater. 45, 2463–2467 (2016). https://doi.org/10.1007/s11664-016-4374-z

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  • DOI: https://doi.org/10.1007/s11664-016-4374-z

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