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Optimization of the Electrophoretic Deposition Parameters for Biocomposite Hydroxyapatite/Chitosan/Collagen/h-BN Coatings on Ti6Al4V Biomedical Implants

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Abstract

Ti6Al4V alloy biomedical implant materials were coated with a biocomposite hydroxyapatite/chitosan/collagen/h-BN layer using electrophoretic deposition at room temperature. Response surface methodology (RSM) and central composite design (CCD) were employed for modeling and optimizing the electrophoretic deposition parameters of chitosan concentration, deposition potential, and agitation speed. The mutual effects of these parameters on the responses (deposition yield and Ecorr) have been analyzed and displayed by response surface plots. Predicted and experimental values agreed well with each other. The average absolute errors between experimental and predicted values were calculated as 2.0 and 2.2 pct for response-1 (deposition yield) and response-2 (Ecorr), respectively. A 5-level-3-factor experimental design has been utilized to optimize electrophoretic deposition parameters. According to deposition yield and Ecorr models, optimized values were for chitosan concentration: 2.57 and 2.59 g/L, for deposition potential: 16.09 and 16.25 V, and for agitation speed: 247 and 229 rpm, respectively. The findings of this research suggest that statistical design methodologies (i.e., RSM and CCD) may effectively be employed for the modeling and optimizing of multi-electrophoretic deposition parameters. These results are encouraging and may be practiced for functionalization of Ti6Al4V biomedical implant devices to provide better in vivo biocompatibility performance.

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Acknowledgment

Financial support for this research by the Mustafa Kemal University Scientific Research Projects through the grant from Mustafa Kemal University Research Foundation (Project No. 13920) is gratefully acknowledged.

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Authors and Affiliations

  1. Physics Department, Faculty of Art and Science, Mustafa Kemal University, 31034, Hatay, Turkey

    Ali Tozar & İsmail Hakki Karahan

  2. Chemistry Department, Faculty of Art and Science, Mustafa Kemal University, 31034, Hatay, Turkey

    Yasin Yücel

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  1. Ali Tozar
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Correspondence to Ali Tozar.

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Manuscript submitted January 10, 2018.

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Tozar, A., Karahan, İ.H. & Yücel, Y. Optimization of the Electrophoretic Deposition Parameters for Biocomposite Hydroxyapatite/Chitosan/Collagen/h-BN Coatings on Ti6Al4V Biomedical Implants. Metall Mater Trans A 50, 1009–1020 (2019). https://doi.org/10.1007/s11661-018-5010-8

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