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Physiopathologie de l’hyperactivité vésicale

Pathophysiology of bladder overactivity

  • Article de Synthèse / Review Article
  • Published:
La Lettre de médecine physique et de réadaptation

Résumé

L’hyperactivité vésicale est définie comme un trouble de la continence associant une urgenturie avec ou sans incontinence, et fréquemment associée à une pollakiurie et à une nycturie. Un ensemble d’observations récentes permet en effet, désormais, d’établir que l’hyperactivité vésicale correspond d’abord à une anomalie du traitement sensoriel régulant la continence. Les différents cadres étiopathogéniques chez l’homme partagent un ensemble de désordres similaires au niveau de l’urothélium, des nerfs et du muscle lisse du détrusor. Ces désordres s’inscrivent pour partie dans le cadre d’une neuroplasticité orchestrée par les facteurs de croissance nerveuse.

Abstract

Overactive bladder (OAB) is characterised by the storage symptoms of urgency, with or without incontinence, and usually with urinary frequency and nocturia. Recent findings establish that OAB may first refer to abnormal sensory processing of continence. The various pathologic conditions associated with OAB share common features of altered function of urothelium, innervation and detrusor smooth muscle, and may partly rely on growth factors that orchestrate neural plasticity.

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Authors and Affiliations

  1. Service de rééducation neurologique adulte, CMRRF Kerpape, BP 78, F-56275, Ploemeur cedex, France

    J. Kerdraon & P. Coignard

  2. Pavillon Pointeau du Ronceray, centre de référence spina bifida, CHU Pontchaillou, 2, rue Henri-Le-Guilloux, F-35000, Rennes, France

    J. Kerdraon, A. Manunta & L. Siproudhis

Authors
  1. J. Kerdraon
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  2. A. Manunta
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  3. P. Coignard
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  4. L. Siproudhis
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Correspondence to J. Kerdraon.

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Kerdraon, J., Manunta, A., Coignard, P. et al. Physiopathologie de l’hyperactivité vésicale. Lett Med Phys Readapt 26, 69–73 (2010). https://doi.org/10.1007/s11659-010-0228-x

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  • DOI: https://doi.org/10.1007/s11659-010-0228-x

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