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Assessment of calcium and vitamin D medications adherence in patients with hypoparathyroidism after thyroidectomy

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Abstract

Summary

In this study, we found that patients with hypoparathyroidism had a problem with calcium medication compliance, and this problem increased with the duration of the disease. We also showed that patients are concerned about the possible side effects of drugs.

Introduction

In this study, we aimed to evaluate adherence to active vitamin D and calcium replacement in patients with post-surgical hypoparathyroidism.

Methods

To elucidate the medication adherence, we performed a questionnaire survey using the six-item “Medication adherence questionnaire”(MAQ). The first, second, and sixth questions reflect the motivation status of the patients whereas the third, fourth, and fifth questions reflect the knowledge about the medication that is received. The responses are scored and patients are classified regarding their motivation to and knowledge about the particular drug.

Results

Totally, 64 patients (male: 12/female: 52; mean age 48.6±11.6 years) who had post-operative hypoparathyroidism were included in our study. Median disease durance was 60 months (min–max: 12–295 months). We found that motivation score of calcium usage was significantly lower compared to vitamin D usage (p<0.001). The calcium motivation score was reversely correlated with disease duration (r= −0.256 and p=0.046). The most common worry about calcium usage was nephrotoxicity, and the most common worries about calcitriol treatment were kidney damage and polyuria. One-third of the patients were taking oral calcium and calcitriol less than the recommended dose.

Conclusion

One-third of patients lack motivation to use calcium whereas half of the patients experiences anxiety about drug-related side effects. This is a preliminary study showing that vital calcium and active vitamin D intake may be interrupted due to side effect anxiety.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Endocrinology and Metabolism, Karadeniz Technical University, Trabzon, Turkey

    Muhammet Cuneyt Bilginer

  2. Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara Yıldırım Beyazıt University, Ankara, Turkey

    Cevdet Aydin, Burcak Polat, Oya Topaloglu, Reyhan Ersoy & Bekir Cakir

  3. Department of Endocrinology and Metabolism, University of Health Sciences Turkey, Ankara City Hospital, Ankara, Turkey

    Sevgul Faki

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  1. Muhammet Cuneyt Bilginer
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  2. Cevdet Aydin
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Correspondence to Muhammet Cuneyt Bilginer.

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The study protocol was approved by Ankara Ataturk Education and Research Hospital and complied with the principles of the Declaration of Helsinki

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Bilginer, M.C., Aydin, C., Polat, B. et al. Assessment of calcium and vitamin D medications adherence in patients with hypoparathyroidism after thyroidectomy. Arch Osteoporos 17, 22 (2022). https://doi.org/10.1007/s11657-022-01066-0

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