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The association between hepatitis and osteoporosis: a nested case-control study using a national sample cohort

Archives of Osteoporosis volume 14, Article number: 34 (2019) Cite this article

Abstract

Summary

The prevalence of hepatitis B was higher in osteoporosis patients than the control group, especially in females. However, the prevalence of hepatitis C was not different. The matching for various factors improved to have same conditions between osteoporosis patients and the control group.

Purpose

Although chronic liver disease, including hepatitis B and hepatitis C, has been associated with osteoporosis in previous studies, the evidence was insufficient, and some findings were inconsistent. The aim of this study was to evaluate the relationship between hepatitis B or hepatitis C and osteoporosis.

Methods

We used the Korean National Health Insurance Service-National Sample Cohort with ≥ 50-year-old participants from 2002 to 2013. Age was determined at osteoporosis diagnosis. We extracted 68,492 osteoporosis patients (ICD-10 codes E7001–E7004, HC341–HC345) with a 68,492-member control group at a ratio of 1:1 by age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed previous histories of hepatitis B (ICD-10 codes B18.0–B18.1) and hepatitis C (ICD-10 code B18.2) in the osteoporosis patients and control groups. The logistic regression with the crude and adjusted model was analyzed. Additionally, subgroup analyses divided by age and sex were performed.

Results

The adjusted odds ratios for hepatitis B and hepatitis C were 1.19 (95% confidence interval (CI) = 1.11–1.28, P < 0.001) and 1.04 (95% CI = 0.90–1.19, P > 0.05), respectively, in osteoporosis patients. Subgroup analyses showed that the risk of hepatitis B was higher in osteoporosis patients in female groups but not in male groups.

Conclusion

Hepatitis B virus infection might be a risk factor for osteoporosis.

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Fig. 1

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Acknowledgments

The manuscript was edited for proper English language, grammar, punctuation, spelling, and overall style by the highly qualified native English-speaking editors at American Journal Experts (EF6A-C642-3739-A20A-499P).

Funding

This work was supported by the Hallym University Research Fund and in part by a research grant (NRF-2018-R1D1A1A02085328) from the National Research Foundation (NRF) of Korea.

Author information

Affiliations

  1. Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, South Korea

    Chanyang Min & Hyo Geun Choi

  2. Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, South Korea

    Chanyang Min & Hyo Geun Choi

  3. Graduate School of Public Health, Seoul National University, Seoul, South Korea

    Chanyang Min

  4. Department of Urology, Hallym University College of Medicine, Anyang, South Korea

    Woo Jin Bang

  5. Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, South Korea

    Miyoung Kim

  6. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Dong Jun Oh

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  1. Chanyang Min
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Corresponding author

Correspondence to Hyo Geun Choi.

Ethics declarations

The Ethics Committee of Hallym University (2014-I148) approved the use of the data from the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC). The Institutional Review Board waived the requirement for written informed consent.

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Min, C., Bang, W.J., Kim, M. et al. The association between hepatitis and osteoporosis: a nested case-control study using a national sample cohort. Arch Osteoporos 14, 34 (2019). https://doi.org/10.1007/s11657-019-0590-5

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  • DOI: https://doi.org/10.1007/s11657-019-0590-5

Keywords

  • Hepatitis B
  • Hepatitis C
  • Infection
  • Liver disease
  • Osteoporosis
  • Bone loss