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Bone metabolism markers and vitamin D in adolescent cyclists

Abstract

Summary

This study aimed to describe bone metabolic activity in adolescent competitive cyclists compared to age-matched controls. The main result is that younger subjects present a higher bone turnover than the older ones. Moreover, cyclists under the age of 17 have higher scores on all markers than age-matched controls.

Purpose

The purpose of this study was to describe bone metabolic activity in adolescent competitive cyclists compared to age-matched controls.

Methods

Twenty-two male adolescent cyclists between 14 and 20 years (y) and 20 age-matched controls participated in this study. Serum osteocalcin (OC), aminoterminal propeptide of type I procollagen (PINP), and β-isomerized C-telopeptides (β-CTX) were analyzed by electrochemiluminescence immunoassay (ECLIA); plasma 25 hydroxyvitamin D [25(OH)D] was analyzed by enzyme-linked immunosorbent assay (ELISA).

Results

Analysis of variance revealed no significant differences in bone metabolism markers and vitamin D between cyclists and controls. Cyclists over 17 y had a significantly lower concentration in bone formation and resorption biochemical markers compared to cyclists under 17 y (all P < 0.05). Moreover, controls over 17 y presented lower concentration for PINP (P < 0.05) compared to their peers under 17 y. Comparisons between cyclists and controls under 17 y revealed higher concentrations of OC and PINP (P < 0.05) in cyclists. Group interaction by age was found for OC, PINP, and β-CTX (P < 0.01). Cyclists over 17 y had higher concentrations of [25(OH)D] (P < 0.05) than age-matched controls.

Conclusions

The present results support the idea that cycling during adolescence may be associated to a decrease in bone turnover that may affect bone health later in life.

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Acknowledgments

We wish to thank the controls, cyclists, and their coaches for their diligence and cooperation throughout this study.

Funding

This study has been funded by Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (DPS2008-06999); Presidencia del Gobierno de España, Consejo Superior de Deportes (21/UPB20/10); and Fondo Europeo de Desarrollo Regional (MICINN-FEDER).

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Corresponding author

Correspondence to Germán Vicente-Rodríguez.

Ethics declarations

Written informed consent was obtained from parents and adolescents. The study was performed following the ethical guidelines of the Declaration of Helsinki 1961 (2000 Edinburgh revision). The Ethics Committee of Clinical Research for the Government of Aragón (CEICA; Spain) approved the study protocol.

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Olmedillas, H., Gonzalez-Agüero, A., Rapún-López, M. et al. Bone metabolism markers and vitamin D in adolescent cyclists. Arch Osteoporos 13, 11 (2018). https://doi.org/10.1007/s11657-018-0415-y

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Keywords

  • Cyclists
  • Adolescence
  • Bone turnover
  • Osteocalcin
  • Vitamin D