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Anti-anger Effects of Herbal Medicine: A Mini-Review of Rat Studies

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Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

Abstract

Objective

To analyze the available data on the anti-anger effects of herbal medicines (HMs) as well as their underlying mechanisms in rat models.

Methods

From 6 electronic databases [PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), Wanfang, Oriental Medicine Advanced Searching Integrated System (OASIS), and Research Information Sharing Service (RISS)], relevant animal experiments were searched by using “anger,” “rats,” and “animal” as search keywords. The last search was conducted on November 22, 2019, and all experiments involving rat models of anger and treatment using HMs published until the date of the search were considered.

Results

A total of 24 studies with 16 kinds of HMs were included. Most studies have used the “tail irritating method” and “social isolation and resident intruder” method to establish anger models. According to the included studies, the therapeutic mechanisms of HMs for anger regulation and important herbs by their frequency and/or preclinical evidence mainly incladed regulation of hemorheology (Bupleuri Radix, Paeoniae Radix Alba, and Glycyrrhizae Radix), regulation of sex hormones (Bupleuri Radix, Cyperi Rhizoma, and Paeoniae Radix Alba), regulation of neurotransmitters (Cyperi Rhizoma), regulation of anger-related genes (Bupleuri Radix, Glycyrrhizae Radix, and Paeoniae Radix Alba), and other effects. Overall, Liver (Gan) qi-smoothing herbs including Bupleuri Radix and Cyperi Rhizoma were the most frequently used.

Conclusions

This review found the frequent methods to establish an anger model, and major mechanisms of anti-anger effects of HMs. Interestingly, some Liver qi-smoothing herbs have been frequently used to investigate the anti-anger effects of HM. These findings provide insight into the role and relevance of HMs in the field of anger management.

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Authors and Affiliations

  1. Department of Oriental Neuropsychiatry, Dong-eui University College of Korean Medicine, Busan, 47227, Republic of Korea

    Chan-Young Kwon

  2. Department of Neuropsychiatry, Kyung Hee University Korean Medicine Hospital at Gangdong, 892 Dongnam-ro, Gangdonggu, Seoul, 05278, Republic of Korea

    Hyo-Weon Suh, Jong Woo Kim &  Sun-Yong Chung

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  1. Chan-Young Kwon
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Contributions

CYK and HWS participated in the literature search, study selection and data extraction. CYK and HWS described the manuscript. JWK and SYC supervised the study design and critically reviewed the manuscript. All authors participated in the analysis and interpretation of data and approved the final version for publication.

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Correspondence to Sun-Yong Chung.

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Supported by the Grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, Funded by the Ministry of Health & Welfare, Republic of Korea (No. HF20C0079)

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Kwon, CY., Suh, HW., Kim, J.W. et al. Anti-anger Effects of Herbal Medicine: A Mini-Review of Rat Studies. Chin. J. Integr. Med. 28, 263–271 (2022). https://doi.org/10.1007/s11655-022-3506-3

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