Skip to main content

Advertisement

Log in

Glycyrrhizin-Induced Pseudohyperaldosteronism: A Case Report

  • Case Report
  • Published:
Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Omar HR, Komarova I, El-Ghonemi M, Fathy A, Rashad R, Abdelmalak HD, et al. Licorice abuse: time to send a warning message. Ther Adv Endocrinol Metab 2012;3:125–138.

    Article  Google Scholar 

  2. Fiore C, Eisenhut M, Ragazzi E, Zanchin G, Armanini D. A history of the therapeutic use of liquorice in Europe. J Ethnopharmacol 2005;99:317–324.

    Article  Google Scholar 

  3. Huang Y, Li D, Wang J, Cai Y, Dai Z. GuUGT, a glycosyltransferase from Glycyrrhiza uralensis, exhibits glycyrrhetinic acid 3- and 30-O-glycosylation. Roy Soc Open Sci 2019;6:191121.

    Article  CAS  Google Scholar 

  4. Wang X, Zhang H, Chen L, Shan L, Fan G, Gao X. Liquorice, a unique “guide drug” of traditional Chinese medicine: a review of its role in drug interactions. J Ethnopharmacol 2013;150:781–790.

    Article  CAS  Google Scholar 

  5. Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR. Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age. Lancet 1987;2:821–824.

    Article  CAS  Google Scholar 

  6. Celik MM, Karakus A, Zeren C, Demir M, Bayarogullari H, Duru M, et al. Licorice induced hypokalemia, edema, and thrombocytopenia. Hum Exp Toxicol 2012;31:1295–1298.

    Article  CAS  Google Scholar 

  7. Penninkilampi R, Eslick EM, Eslick GD. The association between consistent licorice ingestion, hypertension and hypokalaemia: a systematic review and meta-analysis. J Hum Hypertens 2017;31:699–707.

    Article  CAS  Google Scholar 

  8. Ferrari P, Krozowski Z. Role of the 11beta-hydroxysteroid dehydrogenase type 2 in blood pressure regulation. Kidney Int 2000;57:1374–1381.

    Article  CAS  Google Scholar 

  9. Kwon YJ, Son DH, Chung TH, Lee YJ. A review of the pharmacological efficacy and safety of Licorice root from corroborative clinical trial findings. J Med Food 2020;23:12–20.

    Article  CAS  Google Scholar 

  10. Straus SM, Kors JA, De Bruin ML, van der Hooft CS, Hofman A, Heeringa J, et al. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol 2006;47:362–367.

    Article  Google Scholar 

  11. Zennaro MC, Boulkroun S, Fernandes-Rosa FL. Pathogenesis and treatment of primary aldosteronism. Nat Rev Endocrinol 2020;16:578–589.

    Article  CAS  Google Scholar 

  12. Sun ZG, Zhao TT, Lu N, Yang YA, Zhu HL. Research progress of glycyrrhizic acid on antiviral activity. Mini Rev Med Chem 2019;19:826–832.

    Article  CAS  Google Scholar 

  13. Liu JY, Zhang CL, Li XP, Liu D. Utilization analysis of hepatoprotecitve drugs of 34 hospitals in Wuhan area during 2012–2014. Chin J Pharmacoepidemiol (Chin) 2016;25:113–118.

    Google Scholar 

  14. Benge E, Shah P, Yamaguchi L, Josef V. Trick or treat? licorice-induced hypokalemia: a case report. Cureus 2020;12:e11656.

    PubMed  PubMed Central  Google Scholar 

  15. Dampali R, Athyros V, Dinas K, Li J, Fan X, Wang Q. Hypertensive crisis with 2 target organ impairment induced by glycyrrhizin: a case report. Gynecol Endocrinol 2018;97:e0073.

    Google Scholar 

  16. Foster CA, Church KS, Poddar M, van Uum SH, Spaic T. Licorice-induced hypertension: a case of pseudohyperaldosteronism due to jelly bean ingestion. Postgrad Med 2017;129:329–331.

    Article  Google Scholar 

  17. Stavropoulos K, Sotiriadis A, Patoulias D. Pseudohyperaldosteronism due to mumijo consumption during pregnancy: a licorice-like syndrome. Gynecol Endocrinol 2018;34:1019–1021.

    Article  CAS  Google Scholar 

  18. Petersen T, Fraissinet F, Ziegler F, Brunel V. An unusual cause of hypokalemia. Clin Chem 2020;66:1575–1576.

    Article  Google Scholar 

  19. Mantani N, Oka H, Watanabe T. A study of factors associated with the development of pseudoaldosteronism in outpatients. J Altern Complement Med 2020;26:329–334.

    Article  Google Scholar 

  20. Athimulam S, Lazik N, Bancos I. Low-renin hypertension. Endocrinol Metab Clin North Am 2019;48:701–715.

    Article  Google Scholar 

  21. He X, Modi Z, Else T. Hereditary causes of primary aldosteronism and other disorders of apparent excess mineralocorticoid activity. Gland Surg 2020;9:150–158.

    Article  Google Scholar 

  22. Wu SY, Wang WJ, Dou JH, Gong LK. Research progress on the protective effects of licorice-derived 18 β-glycyrrhetinic acid against liver injury. Acta Pharmacol Sin 2021;42:18–26.

    Article  CAS  Google Scholar 

  23. Allcock E, Cowdery J. Hypertension induced by liquorice tea. BMJ Case Rep 2015;2015:bcr2015209926.

    Article  Google Scholar 

  24. Li J, Fan X, Wang Q. Hypertensive crisis with 2 target organ impairment induced by glycyrrhizin: a case report. Medicine (Baltimore) 2018;97:e0073.

    Article  Google Scholar 

  25. Sigurjónsdóttir HA, Franzson L, Manhem K, Ragnarsson J, Sigurdsson G, Wallerstedt S. Liquorice-induced rise in blood pressure: a linear dose-response relationship. J Hum Hypertens 2001;15:549–552.

    Article  Google Scholar 

  26. Farese Jr RV, Biglieri EG, Shackleton CH, Irony I, Gomez-Fontes R. Licorice-induced hypermineralocorticoidism. N Engl J Med 1991;325:1223–1227.

    Article  Google Scholar 

  27. Epstein MT, Espiner EA, Donald RA, Hughes H. Effect of eating liquorice on the renin-angiotensin aldosterone axis in normal subjects. Br Med J 1977;1:488–490.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

Fan ZJ and Li XX contributed to preparation and critical revision of manuscript; Liu JM, Cui J, Zhuang R, and Lin Q analyzed the data; Wu ZB collected the samples; Guo B coordinated the clinical care of the patient; Wu Y contributed to conception and critical revision of manuscript and supervision. All authors read and approved the final manuscript for publication.

Corresponding author

Correspondence to Yang Wu.

Ethics declarations

None.

Additional information

Supported by National Natural Science Foundation of China (No. 81573900)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fan, Zj., Liu, Jm., Li, Xx. et al. Glycyrrhizin-Induced Pseudohyperaldosteronism: A Case Report. Chin. J. Integr. Med. 28, 644–649 (2022). https://doi.org/10.1007/s11655-021-3312-y

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11655-021-3312-y

Navigation