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From Molecular Pathology of COVID 19 to Nigella Sativum as a Treatment Option: Scientific Based Evidence of Its Myth or Reality

Chinese Journal of Integrative Medicine volume 28, pages 88–95 (2022)Cite this article

Abstract

COVID-19 virus is a causative agent of viral pandemic in human beings which specifically targets respiratory system of humans and causes viral pneumonia. This unusual viral pneumonia is rapidly spreading to all parts of the world, currently affecting about 105 million people with 2.3 million deaths. Current review described history, genomic characteristics, replication, and pathogenesis of COVID-19 with special emphasis on Nigella sativum (N. sativum) as a treatment option. N. sativum seeds are historically and religiously used over the centuries, both for prevention and treatment of different diseases. This review summarizes the potential role of N. sativum seeds against COVID-19 infection at levels of in silico, cell lines and animal models.

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Authors and Affiliations

  1. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, 75471, Saudi Arabia

    Muhammad Atif & Muhammad Ikram Ullah

  2. Department of Microbiology, Government College University, Faisalabad, 38000, Pakistan

    Farrah Naz

  3. Department of Microbiology, University of Health Sciences, Lahore, 54600, Pakistan

    Junaid Akhtar, Muhammad Imran & Sidrah Saleem

  4. Department of Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, 40100, Pakistan

    Junaid Akhtar

  5. University of Health Sciences, Lahore, 54600, Pakistan

    Javed Akram

  6. University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, 54590, Pakistan

    Muhammad Imran

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  1. Muhammad Atif
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  2. Farrah Naz
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  3. Junaid Akhtar
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  4. Muhammad Imran
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  5. Sidrah Saleem
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  6. Javed Akram
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  7. Muhammad Imran
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  8. Muhammad Ikram Ullah
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Contributions

Atif M and Imran M designed the study, the first half portion of the manuscript related to COVID-19 was wrote by Naz F and supervised by Atif M. The second half portion of the manuscript related to black seeds was wrote by Akhtar J and supervised by Imran M (from University of Health Science). Saleem S helped in designing the figures. Akram J provided suggestions for the design of review. Imran M and Ullah MI revised the manuscript and replied the revisions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Muhammad Imran.

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No competing financial interests exist.

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Atif, M., Naz, F., Akhtar, J. et al. From Molecular Pathology of COVID 19 to Nigella Sativum as a Treatment Option: Scientific Based Evidence of Its Myth or Reality. Chin. J. Integr. Med. 28, 88–95 (2022). https://doi.org/10.1007/s11655-021-3311-z

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Keywords

  • coronavirus
  • nCoV-19
  • COVID-19
  • Nigella sativum
  • review