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Combination of Activating Blood Circulation and Detoxifying Chinese Medicines Played an Anti-Inflammatory Role in Unstable Angina Patients after Percutaneous Coronary Intervention: A Multicenter, Open-Labeled, Randomized Controlled Trial

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Abstract

Objective

To investigate the combined anti-inflammatory effect of activating blood circulation and detoxifying Chinese medicines in unstable angina (UA) patients.

Methods

This study was an open-labeled, randomized controlled trial conducted in 5 centers in Beijing. A total of 154 patients were randomized into two groups at a 1:1 ratio by random numbers. Based on the conventional treatment, patients in the activating blood circulation (ABC) group were treated with Guanxin Danshen Droping Pill (冠心丹参滴丸, 0.4 g, thrice daily), and patients in the activating blood circulation and detoxifying (ABCD) group were treated with Guanxin Danshen Droping Pill (0.4 g, thrice daily) and Andrographis tablet (0.2 g, thrice daily) for 4 weeks. The primary outcome was the serum level of high sensitive C reaction protein (hs-CRP), and the secondary outcome index included the serum levels of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), soluble CD40 ligand (sCD40L), thrombomodulin (TM), the score of angina pectoris, the score of blood stasis syndrome, and the score of Chinese medicine symptoms, observed at week 0 and week 4.

Results

A total of 144 patients completed the trial (ABC group, n=70; ABCD group, n=74). There were no significant differences in the clinical baseline characteristics between the two groups. When compared with the ABC group, ABCD group showed better performance in reducing the level of inflammatory factors, especially hs-CRP (P<0.05), IL-6 (P<0.01) and TNF-α (P<0.01). In term of clinical symptoms, ABCD group played a better role in improving the scores of angina pectoris and blood stasis syndrome than ABC group (all P<0.05).

Conclusions

The combination of Guanxin Danshen Dropping Pill and Andrographis tablet exert significant anti-inflammatory effect on UA patients, which is superior to single Guanxin Danshen Dropping Pill. (Registration No. ChiCTR-TRC-13004072)

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Authors and Affiliations

  1. National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China

    Xiao-juan Ma, Wen-hui Duan, Ying Zhang, Jie Gao, Bao-yi Guan, Ke-ji Chen & Da-zhuo Shi

  2. Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China

    Xiao-juan Ma, Wen-hui Duan, Ying Zhang, Jie Gao, Bao-yi Guan, Ke-ji Chen & Da-zhuo Shi

Authors
  1. Xiao-juan Ma
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  2. Wen-hui Duan
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  3. Ying Zhang
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  4. Jie Gao
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  5. Bao-yi Guan
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  6. Ke-ji Chen
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  7. Da-zhuo Shi
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Contributions

Ma XJ and Zhang Y were responsible for data collection and analysis and drafted the manuscript. Gao J and Guan BY contributed to the figures and figure legend in manuscript. Chen KJ, Duan WH and Shi DZ conceived and substantially contributed to the design of the study. WD and DS participated in the modification of manuscript for important intellectual content. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Da-zhuo Shi.

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The authors declare that they have no conflict of interests.

Additional information

Supported by the National Natural Science Foundation of China (No. 81573818 and No. 81774141)

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Ma, Xj., Duan, Wh., Zhang, Y. et al. Combination of Activating Blood Circulation and Detoxifying Chinese Medicines Played an Anti-Inflammatory Role in Unstable Angina Patients after Percutaneous Coronary Intervention: A Multicenter, Open-Labeled, Randomized Controlled Trial. Chin. J. Integr. Med. 27, 803–810 (2021). https://doi.org/10.1007/s11655-021-2878-8

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  • DOI: https://doi.org/10.1007/s11655-021-2878-8

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