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Mechanism of ‘Invigorating Qi and Promoting Blood Circulation’ Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology

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Abstract

Objective

Using network pharmacology to explore the mechanism of the ‘invigorating qi and promoting blood circulation’ drug pair Ginseng-Danshen (Salvia miltiorrhiza) on treatment of ischemic heart disease (IHD).

Methods

The chemical constituents of ginseng and Danshen drug pair were identified by searching the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the potential targets of the pair were identified. The pharmacodynamics of the pair was analyzed using network pharmacology. The targets of IHD were identified by database screening. Using protein-protein interaction network, the interaction targets of Ginseng-Danshen on IHD were constructed. A “constituent-target-disease” interaction network was constructed using Cytoscape software, Gene Ontology (GO) term enrichment analysis and biological pathway enrichment analysis were carried out, and the mechanism of improving myocardial ischemia by the Ginseng-Danshen drug pair was investigated.

Results

Seventeen active constituents and 53 targets were identified from ginseng, 53 active constituents and 61 targets were identified from Danshen, and 32 protein targets were shared by ginseng and Danshen. Twenty GO terms were analyzed, including cytokine receptor binding, cytokine activity, heme binding, and antioxidant activity. Sixty Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways were analyzed, including phosphatidylinositol 3-kinase-serine-threonine kinase (PI3K-AKT) signaling pathway, p53 signaling pathway, interleukin 17 signaling pathway, tumor necrosis factor signaling pathway, and the advanced glycation end product (AGE)-the receptor for AGE (RAGE) signaling pathway in diabetic complications.

Conclusion

The specific mechanism of Ginseng-Danshen drug pair in treating IHD may be associated with improving the changes of metabolites inbody, inhibiting the production of peroxides, removing the endogenous oxygen free radicals, regulating the expression of inflammatory factors, reducing myocardial cell apoptosis and promoting vascular regeneration.

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Authors and Affiliations

  1. Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Pharmacology of Chinese Materia, Beijing, 100091, China

    Gao-jie Xin, Yu-wei Zhao, Ling-mei Li, Fei-fan Jia, Xiao Han, Lei Li, Hao Guo, Hong-xu Meng, Jian-hua Fu & Jian-xun Liu

  2. National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China

    Ling-mei Li

Authors
  1. Gao-jie Xin
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  2. Yu-wei Zhao
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  3. Ling-mei Li
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  4. Fei-fan Jia
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  5. Xiao Han
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  6. Lei Li
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  7. Hao Guo
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  8. Hong-xu Meng
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  9. Jian-hua Fu
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  10. Jian-xun Liu
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Contributions

All authors participated in the review of the manuscript. Xin GJ, Fu JH, Li L, and Liu JX conceived and designed the study; Xin GJ, Zhao YW, Li LM and Jia FF performed the study; Guo H and Meng HX analyzed the date; Xin GJ and Han X wrote the paper.

Corresponding author

Correspondence to Jian-hua Fu.

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Conflict of Interest

The authors declare that they have no conflict of interests.

Supported by the National Natural Science Foundation of China (No. 81774145), Youth Program of National Natural Science Foundation of China (No. 81503292); and National Key Basic Research and Development Program (No. 2015cb554406)

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Xin, Gj., Zhao, Yw., Li, Lm. et al. Mechanism of ‘Invigorating Qi and Promoting Blood Circulation’ Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology. Chin. J. Integr. Med. 27, 440–445 (2021). https://doi.org/10.1007/s11655-021-2859-y

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  • DOI: https://doi.org/10.1007/s11655-021-2859-y

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