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Effect of Danhong Injection (丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention

Chinese Journal of Integrative Medicine volume 27, pages 455–460 (2021)Cite this article

Abstract

Objective

To explore the effectiveness of Danhong Injection (丹红注射液) on improving microcirculatory injury after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD).

Methods

A randomized controlled trial was conducted and 90 patients were enrolled. A random sequence was generated using statistical analysis software. Patients with microcirculatory injuries after PCI were randomly divided into 3 groups for treatment (30 subjects in each group): Danhong Injection group: after PCI, Danghong Injections were given with intravenous administration with 40 mL twice a day for a week; statins intensive group: after PCI, atorvastatin calcium tablets were given oral medication with 80 mg once, and then atorvastatin 40 mg daily for 1 week; the control group: after PCI, atorvastatin calcium tablets were given oral medication with 10–20 mg daily for 1 week. The index of microcirculation resistance (IMR) was used to assess microcirculatory injury during PCI. The IMR of the target vessel was reexamined after 1 week of drug treatment.

Results

After one week’s drug treatment, IMR was significantly decreased in both statins intensive group and Danhong Injection group compared with the control group (P<0.01), but no difference was found between statins intensive group and Danhong injection group (14.03 ± 2.54 vs. 16.03 ± 5.72 U, P=0.080).

Conclusions

The efficacy of Danhong Injection is non-inferior to statin. Early use of Danhong Injection after PCI can effectively improve coronary microcirculation injury after PCI.

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Affiliations

  1. Department of Cardiology, Fuwai Hospital of Chinese Academy of Medical Sciences, Beijing, 100037, China

    Qing-rong Liu, Hong-liang Zhang, Hai-tong Zhang, Guang-yuan Song & Yong-jian Wu

  2. Key Laboratory of Cellular Physiology, Ministry of Education (Shanxi Medical University), Taiyuan, China

    Qing-rong Liu

  3. Department of Physiology, Shanxi Medical University, Taiyuan, 030001, China

    Qing-rong Liu

  4. Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, 100010, China

    Hong-xu Liu, Wen-long Xing & Qi Zhou

Authors
  1. Qing-rong Liu
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  2. Hong-xu Liu
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  3. Wen-long Xing
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  4. Qi Zhou
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  5. Hong-liang Zhang
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  6. Hai-tong Zhang
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  7. Guang-yuan Song
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  8. Yong-jian Wu
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Contributions

Liu QR, Liu HX and Wu YJ designed research; Liu QR, Xing WL and Zhou Q analyzed data; Liu QR, Xing WL, Liu HX, Zhang HL, Song GY and Wu YJ performed research; Liu QR and Zhang HT wrote the paper.

Corresponding author

Correspondence to Yong-jian Wu.

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Conflict of Interest

The author declares no conflicts of interest.

Supported by Capital Health Development Research Project (No. 2014-2-4032)

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Liu, Qr., Liu, Hx., Xing, Wl. et al. Effect of Danhong Injection (丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention. Chin. J. Integr. Med. 27, 455–460 (2021). https://doi.org/10.1007/s11655-021-2853-4

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  • DOI: https://doi.org/10.1007/s11655-021-2853-4

Keywords

  • Danhong Injection
  • coronary artery
  • interventional therapy
  • coronary microcirculation injury
  • Chinese medicine