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Effect of Danhong Injection (丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention

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Abstract

Objective

To explore the effectiveness of Danhong Injection (丹红注射液) on improving microcirculatory injury after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD).

Methods

A randomized controlled trial was conducted and 90 patients were enrolled. A random sequence was generated using statistical analysis software. Patients with microcirculatory injuries after PCI were randomly divided into 3 groups for treatment (30 subjects in each group): Danhong Injection group: after PCI, Danghong Injections were given with intravenous administration with 40 mL twice a day for a week; statins intensive group: after PCI, atorvastatin calcium tablets were given oral medication with 80 mg once, and then atorvastatin 40 mg daily for 1 week; the control group: after PCI, atorvastatin calcium tablets were given oral medication with 10–20 mg daily for 1 week. The index of microcirculation resistance (IMR) was used to assess microcirculatory injury during PCI. The IMR of the target vessel was reexamined after 1 week of drug treatment.

Results

After one week’s drug treatment, IMR was significantly decreased in both statins intensive group and Danhong Injection group compared with the control group (P<0.01), but no difference was found between statins intensive group and Danhong injection group (14.03 ± 2.54 vs. 16.03 ± 5.72 U, P=0.080).

Conclusions

The efficacy of Danhong Injection is non-inferior to statin. Early use of Danhong Injection after PCI can effectively improve coronary microcirculation injury after PCI.

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Authors and Affiliations

  1. Department of Cardiology, Fuwai Hospital of Chinese Academy of Medical Sciences, Beijing, 100037, China

    Qing-rong Liu, Hong-liang Zhang, Hai-tong Zhang, Guang-yuan Song & Yong-jian Wu

  2. Key Laboratory of Cellular Physiology, Ministry of Education (Shanxi Medical University), Taiyuan, China

    Qing-rong Liu

  3. Department of Physiology, Shanxi Medical University, Taiyuan, 030001, China

    Qing-rong Liu

  4. Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, 100010, China

    Hong-xu Liu, Wen-long Xing & Qi Zhou

Authors
  1. Qing-rong Liu
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  2. Hong-xu Liu
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  3. Wen-long Xing
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  4. Qi Zhou
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  5. Hong-liang Zhang
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  6. Hai-tong Zhang
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  7. Guang-yuan Song
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  8. Yong-jian Wu
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Contributions

Liu QR, Liu HX and Wu YJ designed research; Liu QR, Xing WL and Zhou Q analyzed data; Liu QR, Xing WL, Liu HX, Zhang HL, Song GY and Wu YJ performed research; Liu QR and Zhang HT wrote the paper.

Corresponding author

Correspondence to Yong-jian Wu.

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Conflict of Interest

The author declares no conflicts of interest.

Supported by Capital Health Development Research Project (No. 2014-2-4032)

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Liu, Qr., Liu, Hx., Xing, Wl. et al. Effect of Danhong Injection (丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention. Chin. J. Integr. Med. 27, 455–460 (2021). https://doi.org/10.1007/s11655-021-2853-4

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  • DOI: https://doi.org/10.1007/s11655-021-2853-4

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