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Effects of Bushen Yiqi Huoxue Decoction in Treatment of Patients with Diminished Ovarian Reserve: A Randomized Controlled Trial

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Abstract

Objective

To explore the therapeutic effect of Bushen Yiqi Huoxue Decoction BYHD) in patients with diminished ovarian reserve (DOR).

Methods

A total of 180 patients with DOR diagnosed from December 2013 to December 2014 were equally assigned into progynova and duphaston (E+D) group, Zuogui Pill group and BYHD group with 60 cases in each by computerized randomization. Patients received E+D, Zuogui Pill or BYHD for 12 months, respectively. Follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), anti-Müllerian hormone (AMH), antral follicle count (AFC), ovarian volume, endometrial thickness, and the resistance indices (RIs) of ovarian arteries and uterine arteries were observed before and after treatment.

Results

Nine women (4 from the E+D group, 3 from the Zuogui Pill group, and 2 from the BYHD group) withdrew from the study. After 6 months, Zuogui Pill and BYHD significantly decreased FSH and LH and increased endometrial thickness and AMH (all P<0.01). BYHD also resulted in E2 elevation (P<0.05), ovary enlargement (P<0.05), AFC increase (P<0.01), and RI of ovarian arteries decrease (P<0.05). After 12 months, further improvements were observed in the Zuogui Pill and BYHD groups (all P<0.01), but BYHD showed better outcomes, with lower FSH, larger ovaries and a thicker endometrium compared with the Zuogui Pill group (all P<0.01). However, E+D only significantly increased endometrial thickness (P<0.01) and no significant improvements were observed in the RI of uterine arteries in the three groups.

Conclusions

BYHD had a favorable therapeutic effect in patients with DOR by rebalancing hormone levels, promoting ovulation, and repairing the thin endometrium. The combination of tonifying Shen (Kidney), benefiting qi and activating blood circulation may be a promising therapeutic strategy for DOR.

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Authors and Affiliations

  1. Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, 200000, China

    Jing Zhou, Xin-yao Pan, Jin Lin, Lan Wang, Yan Sun &  Ling Wang

  2. Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200000, China

    Jing Zhou, Xin-yao Pan, Jin Lin, Lan Wang, Yan Sun &  Ling Wang

  3. Academy of Integrative Medicine of Fudan University, Shanghai, 200000, China

    Jing Zhou, Xin-yao Pan, Jin Lin, Lan Wang, Yan Sun &  Ling Wang

  4. Yangpu Hospital of Traditional Chinese Medicine, Shanghai, 200000, China

    Qi Zhou

  5. Second Affiliated Hospital of Hexi University, Zhangye, Gansu Province, 743000, China

    Li-kun Lan

  6. Department of Obstetrics and Gynecology, Wenling People’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325000, China

    Jun Zhu

  7. Regulatory Commission Office of the New Cooperative Medical Scheme, Eryuan County, Dali, Yunnan Province, 671000, China

    Ru Duan

Authors
  1. Jing Zhou
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  2. Xin-yao Pan
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  3. Jin Lin
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  4. Qi Zhou
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  5. Li-kun Lan
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  6. Jun Zhu
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  7. Ru Duan
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  8. Lan Wang
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  9. Yan Sun
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  10. Ling Wang
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Contributions

Zhou J and Pan XY contributed equally to this work including writing paper and performing the analysis with constructive discussions. Lin J, Zhou Q, Lan LK, Wang L and Sun Y collected the information of clinic samples and reviewed the manuscript. Zhu J and Duan R performed the clinical trial and analyzed data. Wang L contributed the conception of the study, clinical trial design and paper writing.

Corresponding author

Correspondence to Ling Wang.

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There is no conflict to disclose.

Additional information

Supported by the 2018 Program to Guide Medicine of the Shanghai Municipal Science and Technology Commission (No. 18401902200), Special Project of the China Resources Sanjiu Medical and Pharmaceutical Co. and the Obstetrics & Gynecology Special Committee, the Chinese Association for the Integration of Traditional and Western Medicine (No. CR1901FC01)

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Zhou, J., Pan, Xy., Lin, J. et al. Effects of Bushen Yiqi Huoxue Decoction in Treatment of Patients with Diminished Ovarian Reserve: A Randomized Controlled Trial. Chin. J. Integr. Med. 28, 195–201 (2022). https://doi.org/10.1007/s11655-020-3484-x

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  • DOI: https://doi.org/10.1007/s11655-020-3484-x

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