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Combating Drug Resistance in Colorectal Cancer Using Herbal Medicines

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Abstract

Colorectal cancer (CRC) is one of the most prevalent and lethal cancer types around the world. Most of the CRC patients are treated with chemotherapeutic drugs alone or combined. However, up to 90% of metastatic cancer patients experience the failure of treatment mostly because of the acquired drug resistance, which can be led to multidrug resistance (MDR). In this study, we reviewed the recent literature which studied potential CRC MDR reversal agents among herbal medicines (HMs). Among abundant HMs, 6 single herbs, Andrographis paniculata, Salvia miltiorrhiza, Hedyotis diffusa, Sophora flavescens, Curcuma longa, Bufo gargarizans, and 2 formulae, Pien Tze Huang and Zhi Zhen Fang, were found to overcome CRC MDR by two or more different mechanisms, which could be a promising candidate in the development of new drugs for adjuvant CRC chemotherapy.

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Authors and Affiliations

  1. Department of Clinical Oncology, Cheonan Korean Medicine Hospital of Daejeon University, Cheonan, 31099, Republic of Korea

    Ga-Young Lee & Nam-Hun Lee

  2. Liver & Immunology Research Center, Dunsan Korean Medicine Hospital of Daejeon University, Daejeon, 35235, Republic of Korea

    Ga-Young Lee, Jin-Seok Lee, Chang-Gue Son & Nam-Hun Lee

  3. Department of Internal Medicine, Graduated School of Korean Medicine, University of Daejeon, Daejeon, 34520, Republic of Korea

    Ga-Young Lee, Jin-Seok Lee, Chang-Gue Son & Nam-Hun Lee

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  1. Ga-Young Lee
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  2. Jin-Seok Lee
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  3. Chang-Gue Son
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  4. Nam-Hun Lee
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Correspondence to Nam-Hun Lee.

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Supported by the Daejeon University Research Grants (2017)

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Lee, GY., Lee, JS., Son, CG. et al. Combating Drug Resistance in Colorectal Cancer Using Herbal Medicines. Chin. J. Integr. Med. 27, 551–560 (2021). https://doi.org/10.1007/s11655-020-3425-8

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