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Hotspot Analysis of Traditional Drugs in Diabetes Treatment Literature

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Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

Abstract

Objective

To summarize current hotspots and predict the potential trends in traditional drugs of diabetes treatment for further research.

Methods

Publications on the application of traditional drugs in diabetes treatment were searched from PubMed without language limits. Highly frequent MeSH terms were identified through Bibliographic Item Co-Occurrence Matrix Builder (BICOMB). Biclustering analysis results were visualized utilizing the gCLUTO software. Finally, a strategic diagram was generated.

Results

Totally 2,386 relevant publications were obtained from PubMed on November 9th, 2018, and 69 highly frequent MeSH terms were identified. Biclustering analysis revealed that these highly frequent MeSH terms were classified into 7 clusters. After calculating the density and centrality of each cluster, strategy diagram was presented. Cluster 0 “Chinese medicine monomers such as antioxidant and hypoglycemic effects” was considered as the most potential research hotspot.

Conclusions

In this study, we found 7 topics related to the application of traditional drugs in diabetes treatment. The molecular mechanisms of Chinese medicine monomers in diabetes could become a potential hotspot with high centricity and low density.

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Author information

Authors and Affiliations

  1. Department of Traditional Chinese Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, China

    Hui Shen & Wei-kai Zhu

  2. Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, China

    Zhi Lu

  3. Department of Endocrinology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, China

    Hai-cheng Zhou

Authors
  1. Hui Shen
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  2. Wei-kai Zhu
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  4. Hai-cheng Zhou
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Contributions

Zhou HC conceived and designed the study. Shen H and Zhu WK conducted most of the experiments and data analysis, and wrote the manuscript. Lu Z participated in collecting data and helped to draft the manuscript. All authors reviewed and approved the manuscript.

Corresponding author

Correspondence to Hai-cheng Zhou.

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Conflict of Interest

The authors declare no conflicts of interest.

Supported by the Scientific Research Project for Institutes of Higher Education, Ministry of Education, Liaoning Province (No. L2015160)

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Shen, H., Zhu, Wk., Lu, Z. et al. Hotspot Analysis of Traditional Drugs in Diabetes Treatment Literature. Chin. J. Integr. Med. 27, 304–312 (2021). https://doi.org/10.1007/s11655-020-3322-1

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