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Shenqi Fuzheng Injection (参芪扶正注射液) Combined with Chemotherapy for Acute Leukemia: A Meta-Analysis

  • Evidence-Based Integrative Medicine
  • Published:
Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

Abstract

Objective

To evaluate to the efficacy and safety of Shenqi Fuzheng Injection (参芪扶正注射液, SFI) combined with chemotherapy in the treatment of acute leukemia (AL) by meta-analysis.

Methods

PubMed, Cochrane library, Embase, SinoMed, China National Knowledge Infrastructure (CNKI), VIP Journal Integration Platform, Wanfang Database were searched from establishment to November 1, 2018. The randomized controlled trials (RCTs) of SFI combined with chemotherapy in the treatment of AL were included. The Cochrane risk assessment form (RevMan 5.1) was used to evaluate the quality of included studies.

Results

A total of 14 RCTs and 1,088 patients was included. The quality evaluation were mostly low risk or unclear. Meta-analysis showed that compared with chemotherapy alone, SFI combined with chemotherapy can improve the total clinical effective rate in patients with AL (RR=1.15, 95% CI: 1.056–1.177; P=0.0001), and relieve adverse reactions caused by chemotherapy drugs, including infection (RR=0.561, 95% CI: 0.397–0.792; P=0.001), nausea and vomiting (RR=0.662, 95% CI: 0.524–0.835; P=0.001), bleeding (RR=0.548, 95% CI: 0.39–0.768; P=0.0001), cardiotoxicity (RR=0.230, 95% CI: 0.080–0.660; P=0.006) and hyperhidrosis (RR=0.348, 95% CI: 0.208–0.581; P=0.0001). The incidence rates of adverse reactions in SFI combined with chemotherapy group were significantly lower than that of the chemotherapy alone group (P<0.01).

Conclusions

Shenqi Fuzheng Injection combined with chemotherapy has good efficacy and safety for AL, and it can alleviate the adverse reactions caused by chemotherapy. However, subject to the limitations of the methodological quality of the literature, the conclusions of this study need to be further verified by large-scale and multi-center RCTs.

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Authors and Affiliations

  1. Department of Hematology and Rheumatology, the Third Affiliated Hospital of Guizhou Medical University, Duyun, Guizhou Province, 558000, China

    Fu-xue Meng, Xin Yang & Mei-ling Li

Authors
  1. Fu-xue Meng
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  2. Xin Yang
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  3. Mei-ling Li
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Contributions

Meng FX designed this study and prepared the manuscript; Yang X and Meng FX researched literature and performed the data analysis, Li ML evaluated the quality of the included study.

Corresponding author

Correspondence to Mei-ling Li.

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Conflict of Interest

The authors have no conflicts of interests.

Supported by Science and Technology Fund Project of Health and Family Planning Commission of Guizhou Province (No. gzwjkj2019-2-006) and the Science and Technology Plan Project of Qiannan Prefecture [Qiannan Keheshezi (2018) No. 36]

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Meng, Fx., Yang, X. & Li, Ml. Shenqi Fuzheng Injection (参芪扶正注射液) Combined with Chemotherapy for Acute Leukemia: A Meta-Analysis. Chin. J. Integr. Med. 28, 81–87 (2022). https://doi.org/10.1007/s11655-020-3264-7

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  • DOI: https://doi.org/10.1007/s11655-020-3264-7

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