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Heat-Clearing Chinese Medicines in Lipopolysaccharide-Induced Inflammation

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Abstract

Lipopolysaccharide (LPS)-induced inflammation causes massive threatening diseases, such as sepsis, acute lung injury and multiple organ dysfunction syndrome. Efficient treatment to prevent inflammation is crucial in LPS-induced inflammatory diseases. Heat-clearing Chinese medicines (CMs) have been used to ameliorate LPS-induced inflammation in China for centuries. Heat-clearing CMs regulate inflammatory pathways, thereby inhibiting the release of inflammatory factors. This review aimed to introduce promising heat-clearing CMs countering LPS-induced inflammation in the last 5 years, exploring the underlying molecular mechanisms.

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Authors and Affiliations

  1. Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China

    Zi-bin Lu, Jin-ying Ou, Hui-hui Cao, Jun-shan Liu & Lin-zhong Yu

Authors
  1. Zi-bin Lu
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  2. Jin-ying Ou
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  3. Hui-hui Cao
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  4. Jun-shan Liu
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  5. Lin-zhong Yu
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Contributions

Yu LZ contributed the conception; Lu ZB contributed to article drafting; Lu ZB, Ou JY, Liu JS and Cao HH joined the literature collection. Final approval was done by Yu LZ.

Corresponding author

Correspondence to Lin-zhong Yu.

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The authors declare no conflict of interest regarding the publication of this article.

Additional information

Supported by National Natural Science Foundation of China (No. 81903886 and 81730110) and China Postdoctoral Science Foundation (No. 2019M652988)

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Lu, Zb., Ou, Jy., Cao, Hh. et al. Heat-Clearing Chinese Medicines in Lipopolysaccharide-Induced Inflammation. Chin. J. Integr. Med. 26, 552–559 (2020). https://doi.org/10.1007/s11655-020-3256-7

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