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Research Progress in Astragalus Membranaceus and Its Active Components on Immune Responses in Liver Fibrosis

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Abstract

The interaction between immune cells and hepatic stellate cells (HSCs) can modulate the development of hepatic fibrosis. It can also regulate hepatic fibrosis and liver cirrhosis caused by excessive deposition of extracellular matrix (ECM). This article reviews the action mechanism of immune cells on liver fibrosis and the effect of Astragalus membranaeus and its active components on immune cells. In-depth study of interaction between immune cells and HSCs on the pathogenesis of liver fibrosis, and the regulatory effect of Astragalus membranaeus and its active components on immune mechanism will provide new insights in the treatment of liver fibrosis.

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Authors and Affiliations

  1. Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi Province, 712046, China

    Yu-tong Liu

  2. Department of Infection, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China

    Wen-liang Lv

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  1. Yu-tong Liu
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  2. Wen-liang Lv
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Correspondence to Wen-liang Lv.

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All authors declared no conflict of interest.

Author Contributions

Liu YT designed the review and wrote the article; Lv WL contributed to the critical revision of the manuscript for important intellectual content.

Supported by the National Natural Science Foundation of China (No.81774282) and Beijing Natural Science Foundation (No. 7172187)

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Liu, Yt., Lv, Wl. Research Progress in Astragalus Membranaceus and Its Active Components on Immune Responses in Liver Fibrosis. Chin. J. Integr. Med. 26, 794–800 (2020). https://doi.org/10.1007/s11655-019-3039-1

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