Radix Astragali (RA), a traditional Chinese medicine from the dried root of Astragalus species, is widely distributed throughout the temperate regions of the world. The major bioactive constituents of RA are triterpene glycosides, flavonoids, saponins, and alkaloids, and these compounds mostly exert pharmacological activities on the cardiovascular, immune, respiratory, and hepatic systems. This review summarizes the recent studies on RA and provides a comprehensive summary regarding the status of resources, ethnopharmacology, phytochemistry, pharmacology, toxicology, clinical application, and patent release of RA. We hope this review can provide a guidance for further development of therapeutic agents from RA.
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There are no conflicts of interest.
Supported by the Science and Technology Innovation Guidance Project, Inner Mongolia Autonomous Region (No. KCBJ2018040), National Nonprofit Industry Research (No. 201507002), the Fourth National Traditional Chinese Medicine Resources Survey Project (No. 43), Science and Technology Planning Project of the Inner Mongolia Autonomous Region, China (No. 201701040), Standardization Project of Mongolian Medicine in Inner Mongolia Autonomous Region (No. 2018-008), Baotou Science and Technology Project (No.CX-2016-17), Scientific Research Foundation Project of Baotou Medical College (No. BYJJ-DF 2017-01), the Inner Mongolia Autonomous Region College Students Innovation and Entrepreneurship Training Program Project (No. 201710127010), Science and Technology Planning Project of the Inner Mongolia Autonomous Region (No. 201503020), China Agriculture Research System (No. CARS-21)
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Zhang, Ch., Yang, X., Wei, Jr. et al. Ethnopharmacology, Phytochemistry, Pharmacology, Toxicology and Clinical Applications of Radix Astragali. Chin. J. Integr. Med. 27, 229–240 (2021). https://doi.org/10.1007/s11655-019-3032-8