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Oral Chinese Herbal Medicine for Depressive Disorder in Patients after Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis

  • Evidence-Based Integrative Medicine
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Abstract

Objective

To evaluate the effectiveness and safety of oral Chinese herbal medicines (CHMs) on post-percutaneous coronary intervention (PCI) patients with depressive disorder in coronary heart disease (CHD).

Methods

A literature search was conducted through databases including PubMed, Cochrane Library, Chinese National Knowledge Infrastructure Databases (CNKI), Chinese Biomedical Literature Database (SinoMed), Chongqing VIP Chinese Science and Technology Periodical Database (VIP) and Wanfang Database up to August 2018. Randomized controlled trials (RCTs) comparing CHMs with placebo or no additional treatments on the basis of standard conventional pharmacological therapies were included. Data extraction, analyses and quality assessment were performed according to the Cochrane standards. RevMan 5.3 software was used to synthesize the results.

Results

A total of 16 RCTs enrolling 1,443 participants were included in this systematic review. When compared with antidepressants alone, CHMs showed similar benefits with less side effects [risk ratio=0.54, 95% confidence interval (CI) 0.43 to 0.69, 582 patients]; meanwhile, the combination therapy may have more advantages than antidepressants alone [mean difference (MD)=–1.03, 95%CI–1.81 to–0.25, 267 patients). When identified with placebo, CHMs seem to have more advantages in relieving depressive symptoms (MD=–19.00, 95%CI–20.02 to–17.98, 189 patients). However, when compared with basic treatment of post- PCI, CHMs showed different results in two trials. In terms of post-PCI related clinical symptoms, CHMs seem to have more advantages in relieving chest pain and other general clinical symptoms. However, the heterogeneity in this review was generally high, it may be caused by different interventions used in each trial and the low quality of the trials.

Conclusions

In total, CHMs showed potentially beneficial effects on depressive symptoms and post-PCI related clinical symptoms. However, because of small sample size and potential bias of most trials, this result should be interpreted with caution. More rigorous trials with larger sample size and higher quality are warranted to give high quality of evidence to support the use of CHMs for CHD complicated with depression.

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Authors and Affiliations

  1. Graduate School, School of Clinical Medicine, Tsinghua University, Beijing, 100084, China

    Ya-jun Xue

  2. Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China

    Ying Xie, Bo-da Zhou, Kun Li, Si-yuan Li & Ping Zhang

  3. Shanxi Tumour Hospital, Taiyuan, 030013, China

    Guo-liang Zhao

Authors
  1. Ya-jun Xue
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  2. Ying Xie
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  3. Guo-liang Zhao
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  4. Bo-da Zhou
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  5. Kun Li
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  6. Si-yuan Li
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  7. Ping Zhang
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Contributions

Xue YJ and Zhao GL was responsible for design of the protocol, data analysis, and draft manuscript. Xie Y and Zhou BD participated in the literatures screening and quality assessment. Li K and Li SY participated in critical revision. Zhao GL and Zhang P participated in conception and design of the study, critical revision and final approval of the manuscript.

Corresponding author

Correspondence to Ping Zhang.

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Conflict of Interest

The authors declare that there is no conflict of interests regarding the publication of this paper.

Supported by the State Key Laboratory of Low-Dimensional Quantum Physics Open Project Fund (No. KF201608)

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Xue, Yj., Xie, Y., Zhao, Gl. et al. Oral Chinese Herbal Medicine for Depressive Disorder in Patients after Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis. Chin. J. Integr. Med. 26, 617–623 (2020). https://doi.org/10.1007/s11655-019-2702-x

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  • DOI: https://doi.org/10.1007/s11655-019-2702-x

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