Bioinformatics Based Therapeutic Effects of Sinomenium Acutum
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To decipher the possible mechanisms of Sinomenium Acutum (SA) in treating diseases by a bioinformatics method.
SA ingredients were searched according to Chinese Pharmacopoeia, Chinese Medicine Dictionary and Traditional Chinese Medicines Database (TCMD). Active compounds and target proteins of SA were acquired through the Pubchem platform. Pathway, network and function analyses of SA were performed with ingenuity pathway analysis (IPA), a bioinformatics analysis platform. Disease, biofunction-target networks were established with Cytoscape.
Eighteen ingredients from SA were obtained. Seven active ingredients with 31 active target proteins were acquired according to PubChem Bioassay test. By IPA analysis, 277 canonical pathways belonging to 17 function categories were collected, 23 kinds of diseases, 21 categories bio-functions were obtained. Based on P value, calculated by IPA, the top 5 signififi cant pathway of SA targets include phosphatidylinositol 3 kinase/Akt (PI3K/Akt) signaling, prostate cancer signaling, macrophage migration inhibitory factor (MIF) regulation of innate immunity, Guanosine-binding protein coupled receptor (GPCR) signaling, and ataxia telangiectasia mutated protein (ATM) signaling. Disease and bio-function network analysis indicated that mitogen activated protein kinase 1 (MAPK1), MAPK3, p65 nuclear factor κB (RELA), nuclear factor of κB inhibitor alpha (NFκBIA), interleukin 1β(IL-1β), prostaglandin G/H synthase 2 (PTGS2) and tumor protein 53 (TP53) were the critical targets in various diseases treated by SA.
In the different view of target, pathway, disease and bio-function, inflfl ammation was found to be a central theme in many chronic conditions. SA could be used not only as an anti-inflfl ammatory agent, but also for the treatment of cancers, neurological diseases, psychological disorders and metabolic diseases.
KeywordsSinomenium Acutum bioinformatics analysis ingenuity pathway analysis network pharmacology
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- 22.Li W, Tan D, Zenali MJ, Brown RE. Constitutive activation of nuclear factor-kappa B (NF-κB) signaling pathway in fi brolamellar hepatocellular carcinoma. Int J Clin Exp Pathol 2010;3:238–243.Google Scholar
- 42.Theiss HD, Brenner C, Engelmann MG, Zaruba MM, Huber B, Henschel V, et al. Safety and effi cacy of SITAgliptin plus GRanulocyte-colony-stimulating factor in patients suffering from acute myocardial infarction (SITAGRAMI-Trial)-rationale, design and first interim analysis. Int J Cardiol 2010;145:282–284.CrossRefPubMedGoogle Scholar
- 47.Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, et al. The p110beta isoform of phosphoinositide 3-kinase signals downstream of G proteincoupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci U S A 2008;105:8292–8297.CrossRefPubMedPubMedCentralGoogle Scholar