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Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics: Two Examples of Rheumatoid Arthritis

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Abstract

Biological complexity and the need for personalized medicine means that biomarker development has become increasingly challenging. Thus, new paradigms for research need to be created that bring together a different classifier of individuals. One potential solution is collaboration between biomarker development and Chinese medicine pattern classification. In this article, two examples of rheumatoid arthritis are discussed, including a new biomarker candidate casein kinase 2 interacting protein 1 (CKIP-1) and a micro RNA 214. The authors obtained a “snapshot” of pattern classification with disease in biomarker identification. Bioinformatics analyses revealed underlying biological functions of two biomarker candidates, in varying degrees, are correlated with Chinese medicine pattern of rheumatoid arthritis. The authors’ initial attempt can provide a new window for studying the win-win potential correlation between the biomarkers and pattern classification in Chinese medicine.

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Authors and Affiliations

  1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China

    Chi Zhang & Li Li

  2. Institute for Advancing Translational Medicine in Bone and Joint Diseases, Hong Kong Baptist University, Hong Kong SAR, China

    Chi Zhang, Ge Zhang & Ai-ping Lu

  3. Cardiovascular Disease Centre, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China

    Ke-ji Chen

Authors
  1. Chi Zhang
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  2. Li Li
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  3. Ge Zhang
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  4. Ke-ji Chen
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  5. Ai-ping Lu
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Corresponding author

Correspondence to Ai-ping Lu.

Additional information

Supported by the National Natural Science Foundation of China (No. 81503449, 81673773)

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Zhang, C., Li, L., Zhang, G. et al. Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics: Two Examples of Rheumatoid Arthritis. Chin. J. Integr. Med. 27, 465–469 (2021). https://doi.org/10.1007/s11655-018-2571-8

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  • DOI: https://doi.org/10.1007/s11655-018-2571-8

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