Effect of Shen-Fu Injection (参附注射液) on Hemodynamics in Early Volume Resuscitation Treated Septic Shock Patients

Abstract

Objective

To investigate the hemodynamic effect of Shen-Fu Injection (参附注射液, SFI) in early volume resuscitation treated septic shock patients by monitoring pulse indicator continuous cardiac output (PICCO).

Methods

All septic shock patients admitted in the Intensive Care Unit of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 1st, 2014 to December 31th, 2015, were reviewed, and totally 65 were enrolled in this study. They were assigned to SFI group (33 cases) and control group (32 cases). All 65 patients underwent conventional treatment mainly including volume resuscitation, antibiotics and vasoactive drugs therapy. The patients of the SFI group received additional 100 mL of SFI intravenously every 12 h. In all 65 patients, the PICCO arterial catheter and vein catheter were implanted within 1 h after the diagnosis of septic shock. In the course of early volume resuscitation, hemodynamic data of patients were recorded by PICCO monitor at 0, 12, and 24 h after the catheter implantation.

Results

The hemodynamic indices of the two groups showed no significant differences at the beginning of 0 h (P>0.05). At 12 and 24 h, the hemodynamic indices of SFI group were significantly improved in comparison with the control group (P<0.05), including cardiac index (CI), global end diastolic volume index (GEDI), mean arterial pressure (MAP) and heart rate (HR). In addition, there was no significant change of extra-vascular lung water index between the two groups (P>0.05).

Conclusion

SFI significantly improved hemodynamic indices such as CI, GEDI, MAP and HR in early volume resuscitation treated septic shock patients.

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Acknowledgments

We wish to thank all of the doctors and nurses in the ICU of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine for their supports and assistances.

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Correspondence to Kai-liang Fan.

Additional information

Supported by Science and Technology Development Plan of Shandong Province (No. 2012YD19011), Medical and Health Technology Development Plan of Shandong Province (No. 2013WS0250), the National Natural Science Foundation of China (No. 81503543), Traditional Chinese Medicine Science and Technology Development Plan of Shandong Province (No. 2011-095 and 2013-080), Key Development Program of Shandong Province, China (No. 2016GSF202029)

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Fan, K., Wang, J., Kong, L. et al. Effect of Shen-Fu Injection (参附注射液) on Hemodynamics in Early Volume Resuscitation Treated Septic Shock Patients. Chin. J. Integr. Med. 25, 59–63 (2019). https://doi.org/10.1007/s11655-017-2965-z

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Keywords

  • septic shock
  • hemodynamic
  • Shen-Fu Injection
  • Chinese medicine
  • pulse indicator continuous cardiac output