Abstract
Objective
To investigate the hemodynamic effect of Shen-Fu Injection (参附注射液, SFI) in early volume resuscitation treated septic shock patients by monitoring pulse indicator continuous cardiac output (PICCO).
Methods
All septic shock patients admitted in the Intensive Care Unit of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 1st, 2014 to December 31th, 2015, were reviewed, and totally 65 were enrolled in this study. They were assigned to SFI group (33 cases) and control group (32 cases). All 65 patients underwent conventional treatment mainly including volume resuscitation, antibiotics and vasoactive drugs therapy. The patients of the SFI group received additional 100 mL of SFI intravenously every 12 h. In all 65 patients, the PICCO arterial catheter and vein catheter were implanted within 1 h after the diagnosis of septic shock. In the course of early volume resuscitation, hemodynamic data of patients were recorded by PICCO monitor at 0, 12, and 24 h after the catheter implantation.
Results
The hemodynamic indices of the two groups showed no significant differences at the beginning of 0 h (P>0.05). At 12 and 24 h, the hemodynamic indices of SFI group were significantly improved in comparison with the control group (P<0.05), including cardiac index (CI), global end diastolic volume index (GEDI), mean arterial pressure (MAP) and heart rate (HR). In addition, there was no significant change of extra-vascular lung water index between the two groups (P>0.05).
Conclusion
SFI significantly improved hemodynamic indices such as CI, GEDI, MAP and HR in early volume resuscitation treated septic shock patients.
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References
Kim JH. Cardiovascular diseases and Panax ginseng: a review on molecular mechanisms and medical applications. J Ginseng Res 2012;36:16–26.
Ahn HY, Hong SY, Kim JY, Kwon O. Panax ginseng extract rich in ginsenoside protopanaxatriol offers combinatorial effects in nitric oxide production via multiple signaling pathways. Springerplus 2013;2:96.
Wang T, Yu XF, Qu SC, Xu HL, Sui DY. Ginsenoside Rb3 inhibits angiotensin II-induced vascular smooth muscle cells proliferation. Basic Clin Pharmacol Toxicol 2010; 107:685–689.
Guo ZJ, Li CS. Therapeutic effects of Shenfu Injection on post-cardiac arrest syndrome. Chin J Integr Med 2013;19:716–720.
Zheng SD, Wu HJ, Yu SP, Ren JX, Duo WW, Ma ZC, et al. Shenfu Injection suppresses inflammation by targeting haptoglobin and pentraxin 3 in rats with chronic ischemic heart failure. Chin J Integr Med 2015;21:22–28.
Jin YY, Gao H, Zhang XY, Ai H, Zhu XL, Wang J. Shenfu Injection inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock. Chin J Integr Med 2017;23:170–175.
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013;39:165–228.
Gu W, Li C, Yin W, Guo Z, Hou X, Zhang D. Shen-Fu Injection reduces postresuscitation myocardial dysfunction in a porcine model of cardiac arrest by modulating apoptosis. Shock 2012;38:301–306.
Li MQ, Pan CG, Wang XM, Mo X, Shi ZX, Xu YJ, et al. Effect of the Shenfu Injection combined with early goaldirected therapy on organ functions and outcomes of septic shock patients. Cell Biochem Biophys 2015;72:807–812.
Dong H, Xiong LZ, Chen M. Study on protective effect of Shenfu Injection on cardiac function of patients undergoing valve replacement. Chin J Integr Tradit West Med (Chin) 2004;24:32–35.
Mou Z, Lv Z, Li Y, Wang M, Xu Q, Yu X. Clinical effect of Shenfu Injection in patients with septic shock: a metaanalysis and systematic review. Evid Based Complement Alternat Med 2015;2015:863149.
Qiu ZL, Ye YP, Zhang N. Clinical efficacy of shenfu injection in treating severe sepsis and its effects on serum levels of interleukin-6 and interleukin-10. Chin J Integr Tradit West Med (Chin) 2012;32:348–351.
Tian X, Gou DM, Cai HJ. Effect of Shenfu Injection on the erythrocyte immune function of patients undergoing cardiopulmonary bypass. Chin J Integr Tradit West Med (Chin) 2011;31:1471–1473.
Ke DZ, Chen QW, Li CL, Li GQ. Cytokines mechanism of shenfu injection in treatment of cardiogenic shock in canine. China J Chin Mater Med (Chin) 2007;32:2273–2277.
Zhang D, Li CS, Guo ZJ, Yin WP, Hou XM. Comparison of Shenfu Injection and epinephrine on catecholamine levels in a porcine model of prolonged cardiac arrest. Chin J Integr Med 2016;22:370–376.
Acknowledgments
We wish to thank all of the doctors and nurses in the ICU of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine for their supports and assistances.
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Supported by Science and Technology Development Plan of Shandong Province (No. 2012YD19011), Medical and Health Technology Development Plan of Shandong Province (No. 2013WS0250), the National Natural Science Foundation of China (No. 81503543), Traditional Chinese Medicine Science and Technology Development Plan of Shandong Province (No. 2011-095 and 2013-080), Key Development Program of Shandong Province, China (No. 2016GSF202029)
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Fan, Kl., Wang, Jh., Kong, L. et al. Effect of Shen-Fu Injection (参附注射液) on Hemodynamics in Early Volume Resuscitation Treated Septic Shock Patients. Chin. J. Integr. Med. 25, 59–63 (2019). https://doi.org/10.1007/s11655-017-2965-z
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DOI: https://doi.org/10.1007/s11655-017-2965-z