Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial

Abstract

Objective

To evaluate Chinese medicine (CM) formula Bazheng Powder (八正散) as an alternative therapeutic option for female patients with recurrent urinary tract infection (RUTI).

Methods

A randomized double-blinded trial was performed. Eligible female patients with RUTI were recruited from one hospital and two community health centers. By using a blocked randomization scheme, participants were randomized to receive a CM formula (10 herbs) for 4 weeks or antibiotics for 1 week, followed by 3 weeks of placebo. Clinical cure rate and microbiological cure and recurrence after treatment were evaluated.

Results

A total 122 eligible patients were enrolled, with 61 cases in each group. The clinical cure rate by the intentto- treatment approach was 90.2% for the CM group and 82.0% for the antibiotics group (P>0.05). Bacteria were cleared from 88.5% (54/61) of patients in the CM group and 82.0% (50/61) in the antibiotics group. The recurrence rate in recovered patients at the 6-month follow-up was 9.1% (5/61) and 14.0 (7/61) in the CM and antibiotics groups, respectively (P>0.05).

Conclusion

CM formula Bazheng Powder is a good alternative option for RUTI treatment. (Registration No. NCT01745328)

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References

  1. 1.

    Foxman B. The epidemiology of urinary tract infection. Nature Rev Urol 2010;7:653–660.

    Article  Google Scholar 

  2. 2.

    Hooton TM. Uncomplicated urinary tract infection. N Engl J Med 2012;366:1028–1037.

    Article  CAS  PubMed  Google Scholar 

  3. 3.

    Beerepoot MA, Geerlings SE, van Haarst EP, van Charante NM, ter Riet G. Nonantibiotic prophylaxis for recurrent urinary tract infections: a systematic review and meta-analysis of randomized controlled trials. J Uroly 2013;190:1981–1989.

    Article  CAS  Google Scholar 

  4. 4.

    Stapleton AE, Au-Yeung M, Hooton TM, Fredricks DN, Roberts PL, Czaja CA, et al. Randomized, placebocontrolled phase 2 trial of a Lactobacillus crispatus probiotic given intravaginally for prevention of recurrent urinary tract infection. Clin Infect Dis 2011;52:1212–1217.

    Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Jiang WY. Therapeutic wisdom in traditional Chinese medicine: a perspective from modern science. Discov Med 2009;5:455–461.

    Google Scholar 

  6. 6.

    Han JN. Treatment of influenza: Chinese medicine vs. Western medicine. J Thoracic Dis 2012;4:10–11.

    Google Scholar 

  7. 7.

    Wang C, Cao B, Liu QQ, Zou ZQ, Liang ZA, Gu L, et al.Oseltamivir compared with the Chinese traditional therapy Maxingshigan-Yinqiaosan in the treatment of H1N1 influenza: a randomized trial. Annal Intern Med 2011;155:217–225.

    Article  Google Scholar 

  8. 8.

    Zhang N, Huang L, Liu S, Wang Y, Luo Y, Jin X, et al. Traditional Chinese medicine: an alternative treatment option for refractory recurrent urinary tract infections. Clin Infect Dis 2013;56:1355.

    Article  PubMed  Google Scholar 

  9. 9.

    Gupta K, Hooton TM, Roberts PL, Stamm WE. Patientinitiated treatment of uncomplicated recurrent urinary tract infections in young women. Annal Intern Med 2001;135:9–16.

    Article  CAS  Google Scholar 

  10. 10.

    Liu SW, Xu XY, Xu J, Yuan JY, Wu WK, Zhang N, et al. Multi-drug resistant uropathogenic Escherichia coli and its treatment by Chinese medicine. Chin J Integr Med 2016.

    Google Scholar 

  11. 11.

    Zheng XY, ed. Guiding principles of clinical research on traditional Chinese drugs. Beijing: China Medic-Pharmaceutical Sciences and Technology Publishing House; 2002.

  12. 12.

    Liu S, Zhang N, Chen Z. Recurrent urinary tract infections caused by multidrug-resistant uropathogenic Escherichia coli: implications for diagnosis and treatment. Eur Urol 2013;63:410–411.

    Article  PubMed  Google Scholar 

  13. 13.

    Leung WK, Wu JC, Liang SM, Chan LS, Chan FK, Xie H, et al. Treatment of diarrhea-predominant irritable bowel syndrome with traditional Chinese herbal medicine: a randomized placebocontrolled trial. Am J Gastroenterol 2006;101:1574–1580.

    Article  PubMed  Google Scholar 

  14. 14.

    Hooton TM, Roberts PL, Stapleton AE. Cefpodoxime vs ciprofloxacin for short-course treatment of acute uncomplicated cystitis: a randomized trial. JAMA 2012;307:583–589.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. 15.

    Jiang M, Zhang C, Zheng G, Guo H, Li L, Yang J, et al. Traditional Chinese medicine Zheng in the era of evidence-based medicine: a literature analysis. Evid Based Complement Alternat Med 2012;2012:409568.

    PubMed  PubMed Central  Google Scholar 

  16. 16.

    Lu NN, Liu Q, Gu LG, Ge SJ, Wu J, Ze-Ji Q, et al. Gene Expression profiles underlying selective T-cell-mediated immunity activity of a Chinese medicine granule on mice infected with influenza virus H1N1. Evid Based Complement Alternat Med 2014;2014:976364.

    PubMed  PubMed Central  Google Scholar 

  17. 17.

    Chen L, Fan J, Li Y, Shi X, Ju D, Yan Q, et al. Modified Jiu Wei Qiang Huo decoction improves dysfunctional metabolomics in influenza A pneumonia-infected mice. Biomed Chromatogr 2014;28:468–474.

    Article  CAS  PubMed  Google Scholar 

  18. 18.

    Mori R, Lakhanpaul M, Verrier-Jones K. Diagnosis and management of urinary tract infection in children: summary of NICE guidance. BMJ 2007;335:395–397.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We would like to thank Editage for providing editorial assistance. We acknowledge the clinical research group members that participated in data collection and analysis for this study.

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Correspondence to Ning Zhang.

Additional information

Supported by Chinese Academy of Traditional Chinese Medicine Joint Innovation Research Project (No. ZZ070808), Traditional Chinese Medicine Dominant Disease Clinical Research Project (No. CACMS08Y0016), and Capital Featured Clinical Application and Promotion Project (No. Z151100004015132), China

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Liu, S., Guo, J., Wu, W. et al. Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial. Chin. J. Integr. Med. 25, 16–22 (2019). https://doi.org/10.1007/s11655-017-2960-4

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Keywords

  • Chinese medicine
  • recurrent urinary tract infection
  • randomized control trial