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Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial

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Abstract

Objective

To evaluate Chinese medicine (CM) formula Bazheng Powder (八正散) as an alternative therapeutic option for female patients with recurrent urinary tract infection (RUTI).

Methods

A randomized double-blinded trial was performed. Eligible female patients with RUTI were recruited from one hospital and two community health centers. By using a blocked randomization scheme, participants were randomized to receive a CM formula (10 herbs) for 4 weeks or antibiotics for 1 week, followed by 3 weeks of placebo. Clinical cure rate and microbiological cure and recurrence after treatment were evaluated.

Results

A total 122 eligible patients were enrolled, with 61 cases in each group. The clinical cure rate by the intentto- treatment approach was 90.2% for the CM group and 82.0% for the antibiotics group (P>0.05). Bacteria were cleared from 88.5% (54/61) of patients in the CM group and 82.0% (50/61) in the antibiotics group. The recurrence rate in recovered patients at the 6-month follow-up was 9.1% (5/61) and 14.0 (7/61) in the CM and antibiotics groups, respectively (P>0.05).

Conclusion

CM formula Bazheng Powder is a good alternative option for RUTI treatment. (Registration No. NCT01745328)

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Acknowledgements

We would like to thank Editage for providing editorial assistance. We acknowledge the clinical research group members that participated in data collection and analysis for this study.

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Authors and Affiliations

  1. Department of Nephrology and Endocrinology, Wangjing Hospital, Chinese Academy of Chinese Medical Science, Beijing, 100102, China

    Shi-wei Liu, Jie Guo & Ning Zhang

  2. Institute of Integrative Medicine, Sun Yat-sen University, Guangzhou, 510275, China

    Wei-kang Wu

  3. Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, 100071, China

    Ze-liang Chen

  4. Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agriculture University, Shenyang, 110866, China

    Ze-liang Chen

Authors
  1. Shi-wei Liu
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  2. Jie Guo
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  3. Wei-kang Wu
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  4. Ze-liang Chen
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  5. Ning Zhang
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Corresponding author

Correspondence to Ning Zhang.

Additional information

Supported by Chinese Academy of Traditional Chinese Medicine Joint Innovation Research Project (No. ZZ070808), Traditional Chinese Medicine Dominant Disease Clinical Research Project (No. CACMS08Y0016), and Capital Featured Clinical Application and Promotion Project (No. Z151100004015132), China

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Cite this article

Liu, Sw., Guo, J., Wu, Wk. et al. Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial. Chin. J. Integr. Med. 25, 16–22 (2019). https://doi.org/10.1007/s11655-017-2960-4

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  • DOI: https://doi.org/10.1007/s11655-017-2960-4

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