Impact of Jumihaidokuto (Shi-Wei-Bai-Du-Tang) on Treatment of Chronic Spontaneous Urticaria: A Randomized Controlled Study



To study the effect of Jumihaidokuto (Shi-Wei-Bai-Du-Tang, 十味败毒汤) in the management of chronic spontaneous urticaria.


A randomized two-arm, parallel group study was conducted to compare the effect of Jumihaidokuto (6 g daily) with a control for 8 weeks. Concomitant therapy (e.g., antihistamines) was continued. Twenty-one subjects with severe chronic urticaria were enrolled in this study. The primary treatment outcome was the severity score proposed by the Japanese Dermatological Association. Secondary outcomes were quality of life (Skindex-16), itch intensity (Visual Analogue Scale), and patients’ subjective disability due to wheal or itch. After the subjects were randomly assigned to groups by block randomization, 10 received Jumihaidokuto, and 11 did not. All subjects had already taken antihistamines.


Improvement was significant when comparing the severity score of the Jumihaidokuto group with that of the control group (P<0.01). Skindex-16 values for both groups gradually decreased in the same fashion.


Concomitant use of Jumihaidokuto with antihistamine was more effective than antihistamine alone in the management of chronic idiopathic urticaria. (Trial Registration No. UMIN000007251)

This is a preview of subscription content, access via your institution.


  1. 1.

    Hide M, Hiragun T, Japanese Dermatological A. Japanese guidelines for diagnosis and treatment of urticaria in comparison with other countries. Allergol Int 2012;61:517–527.

    Article  Google Scholar 

  2. 2.

    Murota H, Kitaba S, Tani M, Wataya-Kaneda M, Azukizawa H, Tanemura A, et al. Impact of sedative and non-sedative antihistamines on the impaired productivity and quality of life in patients with pruritic skin diseases. Allergol Int 2010;59:345–354.

    Article  Google Scholar 

  3. 3.

    Murota H, Kitaba S, Tani M, Wataya-Kaneda M, Katayama I. Effects of nonsedative antihistamines on productivity of patients with pruritic skin diseases. Allergy 2010;65:929–930.

    CAS  Article  Google Scholar 

  4. 4.

    Zhong H, Song Z, Chen W, Li H, He L, Gao T, et al. Chronic urticaria in Chinese population: a hospital-based multicenter epidemiological study. Allergy 2014;69:359–364.

    CAS  Article  Google Scholar 

  5. 5.

    Powell RJ, Leech SC, Till S, Huber PA, Nasser SM, Clark AT, et al. BSACI guideline for the management of chronic urticaria and angioedema. Clin Exp Allergy 2015;45:547–565.

    CAS  Article  Google Scholar 

  6. 6.

    Zuberbier T, Aberer W, Asero R, Bindslev-Jensen C, Brzoza Z, Canonica GW, et al. Methods report on the development of the 2013 revision and update of the EAACI/GA2 LEN/EDF/WAO guideline for the definition, classification, diagnosis, and management of urticaria. Allergy 2014;69:e1–e29.

    CAS  Article  Google Scholar 

  7. 7.

    Altrichter S, Koch K, Church MK, Maurer M. Atopic predisposition in cholinergic urticaria patients and its implications. J Eur Acad Dermatol Venereol 2016;30:2060–2065.

    CAS  Article  Google Scholar 

  8. 8.

    Bailey E, Shaker M. An update on childhood urticaria and angioedema. Curr Opin Pediatr 2008;20:425–430.

    Article  Google Scholar 

  9. 9.

    Long JW, Wang YY, Pi XM, Tu YT. Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine. Chin J Integr Med 2010;16:353–356.

    CAS  Article  Google Scholar 

  10. 10.

    Koseki J, Matsumoto T, Matsubara Y, Tsuchiya K, Mizuhara Y, Sekiguchi K, et al. Inhibition of rat 5alphareductase activity and testosterone-induced sebum synthesis in hamster sebocytes by an extract of Quercus acutissima Cortex. Evid Based Complement Alternat Med 2015;2015:853846.

    Article  Google Scholar 

  11. 11.

    Matsumoto T, Matsubara Y, Mizuhara Y, Sekiguchi K, Koseki J, Tsuchiya K, et al. Plasma pharmacokinetics of polyphenols in a traditional Japanese medicine, jumihaidokuto, which suppresses propionibacterium acnes-induced dermatitisinrats. Molecules 2015;20:18031–18046.

    CAS  Article  Google Scholar 

  12. 12.

    Sekiguchi K, Koseki J, Tsuchiya K, Matsubara Y, Iizuka S, Imamura S, et al. Suppression of propionibacterium acnesinduced dermatitis by a traditional Japanese medicine, Jumihaidokuto, modifying macrophage functions. Evid Based Complement Alternat Med 2015;2015:439258.

    Article  Google Scholar 

  13. 13.

    Hashiro M, Matsumoto C, Takijiri C, Kitaba S, Murota H, Katayama I. Effect of Jumihaidokuto (Shi-Wei-Bai-Du-Tang) on dermatological symptoms of patients with atopic dermatitis evaluation of eruption elements. Skin Res 2011;10:34–40.

    Google Scholar 

  14. 14.

    Okawa A. Clinical efficacy of combination treatment of Ketotifen (HC 20-511) with harbal medicines on chronic urticaria. Med Consult New Remed 1987;24:923–930.

    Google Scholar 

  15. 15.

    Kaneko S, Masuda K, Hiragun T, Inomata N, Furue M, Onozuka D, et al. Transient improvement of urticaria induces poor adherence as assessed by Morisky Medication Adherence Scale-8. J Dermatol 2015;42:1078–1082.

    Article  Google Scholar 

Download references

Author information




KI and HM had made study protocol. KI had randomized the study subjects. HA and HM had contributed to intervention, and accumulated the clinical data. HM performed statistical analysis and wrote this manuscript.

Corresponding author

Correspondence to Hiroyuki Murota.

Additional information

Conflict of Interest

The authors declare no confl icts of interest.

Electronic supplementary material

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Murota, H., Azukizawa, H. & Katayama, I. Impact of Jumihaidokuto (Shi-Wei-Bai-Du-Tang) on Treatment of Chronic Spontaneous Urticaria: A Randomized Controlled Study. Chin. J. Integr. Med. 25, 820–824 (2019).

Download citation


  • Jumihaidokuto
  • crude drug extract
  • Shiwei Baidu Decoction
  • Chinese medicine
  • antihistamine
  • chronic spontaneous urticaria
  • severity
  • quality of life