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Idiosyncratic drug-induced liver injury linked to Polygonum multiflorum: A case study by pharmacognosy

Chinese Journal of Integrative Medicine volume 23, pages 625–630 (2017)Cite this article

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References

  1. Teschke R, Eickhoff A. Herbal hepatotoxicity in traditional and modern medicine: actual key issues and new encouraging steps. Front Pharmacol 2015;6:72.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Teschke R, Zhang L, Long H, Schwarzenboeck A, Schmidt-Taenzer W, Genthner A, et al. Traditional Chinese medicine and herbal hepatotoxicity: a tabular compilation of reported cases. Ann Hepatol 2015;14:7–19.

    Article  PubMed  Google Scholar 

  3. Vuppalanchi R, Navarro V, Vega M, Bonkovsky HL, Seeff L, Serrano J. Herbal dietary supplement associated hepatotoxicity: an upcoming workshop and need for research. Gastroenterology 2015;148:480–482.

    Article  PubMed  PubMed Central  Google Scholar 

  4. The State Pharmacopoeia Commission of People’s Republic of China. Pharmacopoeia of the People’s Republic of China. 1st ed. Beijing: China Medical Science and Technology Press; 2015:175-176, 101-102, 209-225.

  5. But PP, Tomlinson B, Lee KL. Hepatitis related to the Chinese medicine Shou-Wu-Pian manufactured from Polygonum multiflorum. Vet Hum Toxicol 1996;38:280–282.

    CAS  PubMed  Google Scholar 

  6. Cardenas A, Restrepo JC, Sierra F, Correa G. Acute hepatitis due to shen-min: a herbal product derived from Polygonum multiflorum. J Clin Gastroenterol 2006;40:629–632.

    Article  PubMed  Google Scholar 

  7. Cho HC, Min HJ, Ha CY, Kim HJ, Kim TH, Jung WT, et al. Reactivation of pulmonary tuberculosis in a patient with Polygonum multiflorum Thunb-induced hepatitis. Gut Liver 2009;3:52–56.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Jung KA, Min HJ, Yoo SS, Kim HJ, Choi SN, Ha CY, et al. Drug-induced liver injury: twenty five cases of acute hepatitis following ingestion of Polygonum multiflorum Thunb. Gut Liver 2011;5:493–499.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Dong H, Slain D, Cheng J, Ma W, Liang W. Eighteen cases of liver injury following ingestion of Polygonum multiflorum. Complement Ther Med 2014;22:70–74.

    Article  PubMed  Google Scholar 

  10. Lei X, Chen J, Ren J, Li Y, Zhai J, Mu W, et al. Liver damage associated with Polygonum multiflorum Thunb.: a systematic review of case reports and case series. Evid Based Complement Alternat Med 2015;2015:459749.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Mazzanti G, Battinelli L, Daniele C, Mastroianni CM, Lichtner M, Coletta S, et al. New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum multiflorum. Ann Intern Med 2004;140:W30.

    Article  PubMed  Google Scholar 

  12. Park GJ, Mann SP, Ngu MC. Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum. J Gastroenterol Hepatol 2001;16:115–117.

    CAS  Article  PubMed  Google Scholar 

  13. Panis B, Wong DR, Hooymans PM, De Smet PA, Rosias PP. Recurrent toxic hepatitis in a Caucasian girl related to the use of Shou-Wu-Pian, a Chinese herbal preparation. J Pediatr Gastroenterol Nutr 2005;41:256–258.

    Article  PubMed  Google Scholar 

  14. Teschke R, Wolff A, Frenzel C, Eickhoff A, Schulze J. Herbal traditional Chinese medicine and its evidence base in gastrointestinal disorders. World J Gastroenterol 2015;21:4466–4490.

    PubMed  PubMed Central  Google Scholar 

  15. Rochon J, Protiva P, Seeff LB, Fontana RJ, Liangpunsakul S, Watkins PB, et al. Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug-induced liver injury. Hepatology 2008;48:1175–1183.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Danan G, Teschke R. RUCAM in drug and herb induced liver injury: the update. Int J Mol Sci 2015;17.

  17. Laird AR, Ramchandani N, deGoma EM, Avula B, Khan IA, Gesundheit N. Acute hepatitis associated with the use of an herbal supplement (Polygonum multiflorum) mimicking ironoverload syndrome. J Clin Gastroenterol 2008;42:861–862.

    Article  PubMed  Google Scholar 

  18. Furukawa M, Kasajima S, Nakamura Y, Shouzushima M, Nagatani N, Takinishi A, et al. Toxic hepatitis induced by Show-Wu-Pian, a Chinese herbal preparation. Intern Med 2010;49:1537–1540.

    Article  PubMed  Google Scholar 

  19. Bae SH, Kim DH, Bae YS, Lee KJ, Kim DW, Yoon JB, et al. Toxic hepatitis associated with Polygoni Multiflori. Kor J Hepatol 2010;16:182–186.

    Article  Google Scholar 

  20. Banarova A, Koller T, Payer J. Toxic hepatitis induced by Polygonum multiflorum. Intern Med (Slovak) 2012;58:958–962.

    CAS  Google Scholar 

  21. Chalasani NP, Hayashi PH, Bonkovsky HL, Navarro VJ, Lee WM, Fontana RJ. ACG clinical guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol 2014;109:950–966; quiz967.

    Article  PubMed  Google Scholar 

  22. Wang J, Ma Z, Niu M, Zhu Y, Liang Q, Zhao Y, et al. Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum. Front Med 2015;9:457–467.

    Article  PubMed  Google Scholar 

  23. Wang JB, Li CY, Zhu Y, Song HB, Bai ZF, Xiao XX. Integrated evidence chain-based identification of Chinese herbal medicine-induced hepatotoxicity and rational usage: exemplification by Polygonum multiflorum (He Shou Wu). Chin Sci Bull (Chin) 2016;61:971–980.

    Google Scholar 

  24. Chen X, Bian Z, Hou H, Yang F, Liu S, Tang G, et al. Development and validation of a method for the determination of 159 pesticide residues in tobacco by gas chromatography–tandem mass spectrometry. J Agri Food Chem 2013;61:5746–5757.

    CAS  Article  Google Scholar 

  25. Li CY, Tu C, Gao D, Wang RL, Zhang HZ, Niu M, et al. Metabolomic study on idiosyncratic liver injury induced by different extracts of Polygonum multiflorum in rats integrated with pattern recognition and enriched pathways analysis. Front Pharmacol 2016;7:483.

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Yu J, Xie J, Mao XJ, Wang MJ, Li N, Wang J, et al. Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata. J Ethnopharmacol 2011;137:1291–1299.

    CAS  Article  PubMed  Google Scholar 

  27. Ma J, Zheng L, He YS, Li HJ. Hepatotoxic assessment of Polygoni Multiflori Radix extract and toxicokinetic study of stilbene glucoside and anthraquinones in rats. J Ethnopharmacol 2015;162:61–68.

    CAS  Article  PubMed  Google Scholar 

  28. Westendorf J. Anthranoid derivatives — general discussion. In: De Smet PAGM, Keller K, Hänsel R, Chandler R, eds. Adverse effects of herbal drugs. Springer Berlin Heidelberg; 1993:105–118.

    Chapter  Google Scholar 

  29. Wu X, Chen X, Huang Q, Fang D, Li G, Zhang G. Toxicity of raw and processed roots of Polygonum multiflorum. Fitoterapia 2012;83:469–475.

    CAS  Article  PubMed  Google Scholar 

  30. Li CY, Li XF, Tu C, Li N, Ma ZJ, Pang JY, et al. The idiosyncratic hepatotoxicity of Polygonum multiflorum based on endotoxin model. Acta Pharm Sin (Chin) 2015;50:28–33.

    Google Scholar 

  31. Zhang CE, Niu M, Li Q, Zhao YL, Ma ZJ, Xiong Y, et al. Urine metabolomics study on the liver injury in rats induced by raw and processed Polygonum multiflorum integrated with pattern recognition and pathways analysis. J Ethnopharmacol 2016;194:299–306.

    CAS  Article  PubMed  Google Scholar 

  32. Li YM, Li RY, Niu M, Li CY, Bai ZF, Feng WW, et al. Influence of specification on chemical composition of the dissolution and hepatocytes toxicity of Polygonum multiflorum. China J Chin Mater Med (Chin) 2016;41:1033–1039.

    Google Scholar 

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Author information

Affiliations

  1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, China

    Chun-yu Li, Dan Gao & Mei-hua Yang

  2. China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, 100039, China

    Chun-yu Li, Qin He, Dan Gao, Rui-yu Li, Yun Zhu, Wu-wen Feng, Xiao-he Xiao & Jia-bo Wang

  3. School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha, 410208, China

    Qin He

  4. School of Pharmacy, Shanxi University of Traditional Chinese Medicine, Chengdu, 611137, China

    Hui-fang Li

Authors
  1. Chun-yu Li
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  2. Qin He
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  3. Dan Gao
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  4. Rui-yu Li
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  5. Yun Zhu
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  6. Hui-fang Li
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  7. Wu-wen Feng
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  8. Mei-hua Yang
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  9. Xiao-he Xiao
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  10. Jia-bo Wang
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Corresponding author

Correspondence to Jia-bo Wang.

Additional information

Supported by the Being Nova Program (No. Z16111000490000), China’s Post-Doctoral Science Fund (No. 2016M590065), and Beijing Natural Science Foundation (No. 7152142)

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Li, Cy., He, Q., Gao, D. et al. Idiosyncratic drug-induced liver injury linked to Polygonum multiflorum: A case study by pharmacognosy. Chin. J. Integr. Med. 23, 625–630 (2017). https://doi.org/10.1007/s11655-017-2543-9

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  • DOI: https://doi.org/10.1007/s11655-017-2543-9

Keywords

  • chronic urticaria
  • Chinese medicine
  • evidence-based medicine
  • treatment