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Effects of Aidi Injection (艾迪注射液) with Western Medical Therapies on Quality of Life for Patients with Primary Liver Cancer: A Systematic Review and Meta-Analysis

  • Evidence-Based Integrative Medicine
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Abstract

Objective

To evaluate the effects of Aidi Injection (艾迪注射液, AD) in combination with Western medical therapies (WMT) in patients with primary liver cancer (PLC).

Methods

Randomized controlled trials (RCTs) comparing AD plus WMT with WMT alone were retrieved from inception to March 2013 by retrieving the literature database thoroughly and systematically. The extracted data from included studies were analyzed and synthesized by Review Manager 5.2 software. The Cochrane risk of bias tool was used to assess the quality of included studies, and Begg's and Egger's tests were used to evaluate the potential presence of publication bias. The studies were divided into 7 separate subgroups in terms of quality of life (QOL), recent chemotherapy and the incidence of leukocyte reduction. The subgroup analysis was applied to assess the heterogeneity between included researches, and the sensitivity analysis was used to weigh the stability of studies.

Results

Twenty-four RCTs were included in this study. Compared with WMT used alone, AD as additional intervention was more effective on improving QOL (P<0.01), increasing short-term efficacy (P<0.01), prolonging life (P<0.05 or P<0.01), relieving clinical symptoms (P<0.01), and reducing adverse events (e.g. reduce white blood cell counts, P=0.002; reduce in platelet counts, P<0.01). Subgroup analysis showed that the hepatic artery interventions with AD was superior in improving QOL (P<0.01) and enhancing short-term response rates (P=0.007) and reducing white blood cell counts (P=0.0004) than hepatic artery interventions alone (P<0.01). The chemoembolization plus AD or the chemotherapy plus AD were both better than chemoembolization or the chemotherapy alone in improving the QOL and short-term response rate (P<0.05 or P<0.01).

Conclusions

AD in combination with WMT improves QOL in patients with PLC. Considering the inherent limitations of the included studies, further well-designed, rigorously performed, high-quality, and double-blinded RCTs with large sample sizes are needed.

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Authors and Affiliations

  1. Department of Hepatology, Ruikang Hospital Affiliated to Guangxi Chinese Medicine University, Nanning, 530000, China

    Li Liu, Jian Liang & Xin Deng

Authors
  1. Li Liu
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  2. Jian Liang
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  3. Xin Deng
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Contributions

Deng X designed the research project. Liang J was responsible for data analysis. Liu L prepared the manuscript and collected the documents. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Xin Deng.

Additional information

Supported by Guangxi Chinese Medicine Science and Technology Major Projects (No. GZKZ-Z1103) and International Cooperation Projects of the Ministry of Science and Technology (No. S2012ZR0128)

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Liu, L., Liang, J. & Deng, X. Effects of Aidi Injection (艾迪注射液) with Western Medical Therapies on Quality of Life for Patients with Primary Liver Cancer: A Systematic Review and Meta-Analysis. Chin. J. Integr. Med. 25, 785–790 (2019). https://doi.org/10.1007/s11655-017-2426-8

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  • DOI: https://doi.org/10.1007/s11655-017-2426-8

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