Skip to main content
SpringerLink
Log in

Recent highlights of Chinese herbs in treatment of allergic disease: Acting via mitogen-activated protein kinase signal pathway

  • Feature Article
  • Published:
Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

Abstract

The histamine receptor antagonists in the treatment of allergic disease have limitations. The treatments of Chinese herbs have some curative effects on allergic skin lesions. Present research indicates that the mitogen-activated protein kinase (MAPK) signaling pathway might be equally important in allergic reactions. It was found that the inhibition of MAPK signaling pathways might relieve allergy symptoms, and some herbs can inhibit the MAPK pathway, which yields anti-allergy effects. Chinese medicines (CMs) have immense potential in the development of treatments for allergic disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Zuberbier T, Aberer W, Asero R, Bindslev JC, Brzoza Z, Canonica GW, et al. The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update. Allergy 2014;69:868–887.

    Article  CAS  PubMed  Google Scholar 

  2. Li T, Wang H, Chen H, Liu XG, Yang JN, Cajo B, et al. The preliminary study of pseudolaric acid B on specific immune response. Chin Pharm Bull (Chin) 2013;29:184–189.

    CAS  Google Scholar 

  3. Azzolina A, Guarneri P, Lampiasi N. Involvement of p38 and JNK MAPKs pathways in substance P-induced production of TNF-alpha by peritoneal mast cells. Cytokine 2002;18:72–80.

    Article  CAS  PubMed  Google Scholar 

  4. Chen ZJ, Li QS, Li YS, Yu ZF, Yuan JL, Li YK. Pharmacodynamics study on Radix saposhnikoviae (RL) and Feutus tribuli (FI). Chin Tradit Patent Med (Chin) 2003;25:737–739.

    Google Scholar 

  5. Hu HW, Xu XG, Zhang XS, Sun R. Research of extraction and separation technology and anti-allergic effect about fargesin. Chin J Pharm (Chin) 2014;11:261–263.

    Google Scholar 

  6. Xiang FZ, Mei W, Yu YX, Su Z. Effect of composite Salvia Miltirrhiza on hemorrheology of chronic urticaria. Clin Med J China (Chin) 2003;10:602–603.

    Google Scholar 

  7. Yang YJ, An SF, Liang HL. The progress of traditional Chinese medicine experiment research in anti-anaphylaxis. Forum Tradit Chin Med (Chin) 2015;30:67–70.

    Google Scholar 

  8. Asero R. Chronic unremitting urticaria: is the use of antihistamines above the licensed dose effective? A preliminary study of cetirizine at licensed and abovelicensed doses. Clin Exp Dermatol 2007;32:34–38.

    Article  CAS  PubMed  Google Scholar 

  9. Zhu HY, Wu XB, Jin XG, Cui MY, Li TF, Wang MY. The effect of Wumei to mast cell degranulation and the related signaling pathways. Lishizhen Med Mater Med Res (Chin) 2015;26:2096–2098.

    Google Scholar 

  10. Pelaia G, Cuda G, Vatrella A, Gallelli L, Caraglia M, Marra M, et al. Mitogen-activated protein kinases and asthma. J Cell Physiol 2005;202:642–653.

    Article  CAS  PubMed  Google Scholar 

  11. Marchand F, Mecheri S, Guilloux L, Iannascoli B, Weyer A, Blank U. Human serum IgE-mediated mast cell degranulation shows poor correlation to allergen-specific IgE content. Allergy 2003;58:1037–1043.

    Article  CAS  PubMed  Google Scholar 

  12. Williams CM, Galli SJ. The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J Allergy Clin Immunol 2000;105:847–859.

    Article  CAS  PubMed  Google Scholar 

  13. Bradding P, Walls AF, Holgate ST. The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol 2006;117:1277–1284.

    Article  CAS  PubMed  Google Scholar 

  14. Gurish MF, Austen KF. The diverse roles of mast cells. J Exp Med 2001;194:F1–F5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002;298:1911–1912.

    Article  CAS  PubMed  Google Scholar 

  16. Gilfillan AM, Tkaczyk C. Integrated signalling pathways for mast-cell activation. Nat Rev Immunol 2006;6:218–230.

    Article  CAS  PubMed  Google Scholar 

  17. Gschwandtner M, Schäkel K, Werfel T, Gutzmer R. Histamine H(4) receptor activation on human slan-dendritic cells down-regulates their pro-inflammatory capacity. Immunology 2011;132:49–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Zhang HY, Yang J, Long XN, He SH. Signal transduction pathway for TNF-induced IL-6 release from mast cells. J Cell Mol Immunol (Chin) 2011;27:829–831.

    CAS  Google Scholar 

  19. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003;374:1–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Zhang HY, Wang SL, Lin LY, LIN Q, Bei N, He SH. Relationship between IL-13 release of mase cells induced by IL-12 and ERK signaling pathway. J Jilin Univ (Med, Chin) 2009;35:322–325

    CAS  Google Scholar 

  21. Jin GR, Hong H, Jin GY, Li YZ, Li GS, Yan GH. Anthocyanidin inhibits immunoglobulin E-mediated allergic response in mast cells. Acta Pharm Sin (Chin) 2012;47:34–38.

    CAS  Google Scholar 

  22. Huang F, Deng HM, Tong XY. Effect of extracts of ginkgobiloba leaves on activation of RBL-2H3 cell. Chin J Pathophysiol (Chin) 2009;25:1816–1820.

    CAS  Google Scholar 

  23. Liang Z, Wu R, Xie W, Geng H, Zhao L, Xie CF, et al. Curcumin suppresses MAPK pathways to reverse tobacco smoke-induced gastric epithelial-mesenchymal transition in mice. Phytother Res 2015;29:1665–1671.

    Article  CAS  PubMed  Google Scholar 

  24. Zhang ZR, Xu LJ, Sui SQ. Effect of methanol extract of Linghuai Pills on allergic contact dermatitis in mice. Pharm Today (Chin) 2014;24:243–250.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China

    Xu-feng He, Wei-dong Pan, Yi-li Yao & Hui-min Zhang

Authors
  1. Xu-feng He
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wei-dong Pan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yi-li Yao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hui-min Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hui-min Zhang.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

He, Xf., Pan, Wd., Yao, Yl. et al. Recent highlights of Chinese herbs in treatment of allergic disease: Acting via mitogen-activated protein kinase signal pathway. Chin. J. Integr. Med. 23, 570–573 (2017). https://doi.org/10.1007/s11655-016-2526-x

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11655-016-2526-x

Keywords

Search

Navigation