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Chinese Journal of Integrative Medicine

, Volume 24, Issue 3, pp 207–212 | Cite as

Chemical Composition, Anticancer, Anti-neuroinflammatory, and Antioxidant Activities of the Essential Oil of Patrinia scabiosaefolia

  • Jing Lin
  • Qiao-yan Cai
  • Wen Xu
  • Jiu-mao Lin
  • Jun Peng
Original Article
  • 117 Downloads

Abstract

Objective

To study the chemical composition, anticancer, anti-neuroinflflammatory, and antioxidant activities of the essential oil of Patrinia scabiosaefolia (EO-PS).

Methods

Patrinia scabiosaefolia was analyzed by gas chromatography-mass spectrometry. Eight human carcinoma cell lines, including SGC-7901, AGS, HepG2, HT-29, HCT-8, 5-FU/HCT-8, HeLa, and MDA-MB-231, were assessed by methylthiazolyldiphenyltetrazolium bromide (MTT) assay. Anti-neuroinflflammatory activity was assessed by production of interleukin (IL)-1β and IL-6 induced by lipopolysaccharide in BV-2 cells (microglia from mice). The antioxidant activity was evaluated with a 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay.

Results

Forty-four components, representing 83.919% of the total oil, were identifified in the EO-PS. The major constituents were caryophyllene oxide (12.802%), caryophyllene (6.909%), α-caryophyllene (2.927%), β-damascenone (3.435%), calarene (5.621%), and phenol (3.044%). The MTT assay showed that the EO-PS exhibited significant dose-dependent growth inhibition in the 50–200 μg/mL dilution range. The EO-PS exhibited a dose-dependent scavenging activity against the DPPH radical, with an half of maximal inhibitory concentration 1.455 mg/mL.

Conclusions

The EO-PS possesses a wide range of antitumor, anti-neuroinflflammatory and antioxidant activities, suggesting that it may be a good candidate for further investigations of new bioactive substances.

Keywords

Patrinia scabiosaefolia essential oil anti-neuroinflflammatory anticancer antioxidant caryophyllene oxide 

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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine 2016

Authors and Affiliations

  • Jing Lin
    • 1
    • 2
  • Qiao-yan Cai
    • 1
    • 2
  • Wen Xu
    • 1
    • 3
  • Jiu-mao Lin
    • 1
    • 2
  • Jun Peng
    • 1
    • 2
  1. 1.Academy of Integrative Medicine Biomedical Research CenterFujian University of Traditional Chinese MedicineFuzhouChina
  2. 2.Fujian Key Laboratory of Integrative Medicine on GeriatricsFujian University of Traditional Chinese MedicineFuzhouChina
  3. 3.Department of PharmacologyFujian University of Traditional Chinese MedicineFuzhouChina

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