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Chinese Journal of Integrative Medicine

, Volume 22, Issue 6, pp 403–411 | Cite as

Complementary and alternative medicine therapies for chronic pain

  • Brent A. BauerEmail author
  • Jon C. Tilburt
  • Amit Sood
  • Guang-xi Li (李光熙)
  • Shi-han Wang (王师菡)
Feature Article

Abstract

Pain afflflicts over 50 million people in the US, with 30.7% US adults suffering with chronic pain. Despite advances in therapies, many patients will continue to deal with ongoing symptoms that are not fully addressed by the best conventional medicine has to offer them. The patients frequently turn to therapies outside the usual purview of conventional medicine (herbs, acupuncture, meditation, etc.) called complementary and alternative medicine (CAM). Academic and governmental groups are also starting to incorporate CAM recommendations into chronic pain management strategies. Thus, for any physician who care for patients with chronic pain, having some familiarity with these therapies—including risks and benefits—will be key to helping guide patients in making evidence-based, well informed decisions about whether or not to use such therapies. On the other hand, if a CAM therapy has evidence of both safety and efficacy then not making it available to a patient who is suffering does not meet the need of the patient. We summarize the current evidence of a wide variety of CAM modalities that have potential for helping patients with chronic pain in this article. The triad of chronic pain symptoms, ready access to information on the internet, and growing patient empowerment suggest that CAM therapies will remain a consistent part of the healthcare of patients dealing with chronic pain.

Keywords

complementary and alternative medicine therapy chronic pain safety and efficacy 

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References

  1. 1.
    U.S. Department of Health and Human Services. Summary Health Statistics for U.S. Adults: National Interview Survey, 2007. Available at: http://www.cdc.gov/nchs/data/series/sr_10/sr10_240.pdf; May 2009. Accessed July 28, 2015.Google Scholar
  2. 2.
    Johannes CB, Le TK, Zhou X, Johnston JA, Dworkin RH. The prevalence of chronic pain in United States adults: results of an Internet-based survey. J Pain 2010;11:1230–1239.CrossRefPubMedGoogle Scholar
  3. 3.
    Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin RL. Trends in the use of complementary health approaches among adults: United States, 2002–2012. Natl Health Stat Report 2015:1–16.Google Scholar
  4. 4.
    Habermann TM, Thompson CA, LaPlant BR, Bauer BA, Janney CA, Clark MM, et al. Complementary and alternative medicine use among long-term lymphoma survivors: a pilot study. Am J Hematol 2009;84:795–798.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Rausch SM, Winegardner F, Kruk KM, Phatak V, Wahner-Roedler DL, Bauer B. Complementary and alternative medicine: use and disclosure in radiation oncology community practice. Support Care Cancer 2011;19:521–529.CrossRefPubMedGoogle Scholar
  6. 6.
    Wahner-Roedler DL, Elkin PL, Vincent A, Thompson JM, Oh TH, Bauer BA. Use of complementary and alternative medical therapies by patients referred to a fibromyalgia treatment program at a tertiary care center. Mayo Clin Proc 2005;80:55–60.CrossRefPubMedGoogle Scholar
  7. 7.
    Chenot JF, Becker A, Leonhardt C, Keller S, Donner-Banzhoff N, Baum E. Use of complementary alternative medicine for low back pain consulting in general practice: a cohort study. BMC Complement Altern Med 2007;7:42.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    U.S. Department of Veterans Affairs. Proactive pain management: 10 ways to manage your chronic pain. Available at: http://www.publichealth.va.gov/exposures/publications/gulf-war/gulf-war-spring-2015/chronic-painmanagement.asp.; Spring 2015. Accessed July 28, 2015.Google Scholar
  9. 9.
    The Joint Commission Revisions to pain management standard effective January 1, 2015. Available at: http://www.jointcommission.org/issues/article.aspx?Article=5jrML%2fbvKl4ATIYK2naEubuQGABzkaljf6n8eP%2bdPuQ%3d; Accreditation November 12, 2014. Accessed July 28, 2015.Google Scholar
  10. 10.
    Russo E, Scicchitano F, Whalley BJ, Mazzitello C, Ciriaco M, Esposito S. Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions. Phytother Res 2014;28:643–655.CrossRefPubMedGoogle Scholar
  11. 11.
    Ruschitzka F, Meier PJ, Turina M, Luscher TF, Noll G. Acute heart transplant rejection due to Saint John’s wort. Lancet 2000;355:548–549.CrossRefPubMedGoogle Scholar
  12. 12.
    Spinella M. Herbal medicines and epilepsy: the potential for benefit and adverse effects. Epilepsy Behav 2001;2:524–532.CrossRefPubMedGoogle Scholar
  13. 13.
    Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs 2009;69:1777–1798.CrossRefPubMedGoogle Scholar
  14. 14.
    Milic N, Milosevic N, Golocorbin Kon S, Bozic T, Abenavoli L, Borrelli F. Warfarin interactions with medicinal herbs. Nat Prod Commun 2014;9:1211–1216.PubMedGoogle Scholar
  15. 15.
    Schwarz UI, Buschel B, Kirch W. Unwanted pregnancy on self-medication with St John’s wort despite hormonal contraception. Br J Clin Pharmacol 2003;55:112–113.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Lai MY, Yang SP, Chao Y, Lee PC, Lee SD. Fever with acute renal failure due to body massage-induced rhabdomyolysis. Nephrol Dial Transplant 2006;21:233–234.CrossRefPubMedGoogle Scholar
  17. 17.
    Su JW, Lim CH, Chua YL. Bilateral pneumothoraces as a complication of acupuncture. Singapore Med J 2007;48:e32–e33.PubMedGoogle Scholar
  18. 18.
    Linde K, Allais G, Brinkhaus B, Manheimer E, Vickers A, White AR. Acupuncture for migraine prophylaxis. Cochrane Database Syst Rev 2009:CD001218.Google Scholar
  19. 19.
    Brown CA, Jones AK. Meditation experience predicts less negative appraisal of pain: electrophysiological evidence for the involvement of anticipatory neural responses. Pain 2010;150:428–438.CrossRefPubMedGoogle Scholar
  20. 20.
    Mayoclinic.org. Massage: get in touch with its many benefits. Available at: http://www.mayoclinic.org/healthylifestyle/stress-management/in-depth/massage/art-20045743; January 30, 2013. Accessed July 28, 2015.Google Scholar
  21. 21.
    Keeratitanont K, Jensen MP, Chatchawan U, Auvichayapat P. The efficacy of traditional Thai massage for the treatment of chronic pain: A systematic review. Complement Ther Clin Pract 2015;21:26–32.CrossRefPubMedGoogle Scholar
  22. 22.
    Goats GC. Massage—the scientific basis of an ancient art: Part 2. Physiological and therapeutic effects. Br J Sports Med 1994;28:153–156.CrossRefPubMedGoogle Scholar
  23. 23.
    Bowsher D. Modulation of nociceptive input. In: Wells P, Frampton V, Bowsher D, eds. Pain: management and Control in physiotherapy. London, UK: Heinemann Medical; 1988: Chapter13.Google Scholar
  24. 24.
    Hatayama T, Kitamura S, Tamura C, Nagano M, Ohnuki K. The facial massage reduced anxiety and negative mood status, and increased sympathetic nervous activity. Biomed Res 2008;29:317–320.CrossRefPubMedGoogle Scholar
  25. 25.
    Lee SH, Kim JY, Yeo S, Kim SH, Lim S. Meta-analysis of massage therapy on cancer pain. Integr Cancer Ther 2015;14:297–304.CrossRefPubMedGoogle Scholar
  26. 26.
    Somani S, Merchant S, Lalani S. A literature review about effectiveness of massage therapy for cancer pain. J Pak Med Assoc 2013;63:1418–1421.PubMedGoogle Scholar
  27. 27.
    Yuan SL, Matsutani LA, Marques AP. Effectiveness of different styles of massage therapy in fibromyalgia: a systematic review and meta-analysis. Man Ther 2015;20:257–264.CrossRefPubMedGoogle Scholar
  28. 28.
    Li YH, Wang FY, Feng CQ, Yang XF, Sun YH. Massage therapy for fibromyalgia: a systematic review and meta-analysis of randomized controlled trials. PLoS One 2014;9:e89304.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Brosseau L, Wells GA, Poitras S, Tugwell P, Casimiro L, Novikov M. Ottawa Panel evidence-based clinical practice guidelines on therapeutic massage for low back pain. J Bodyw Mov Ther 2012;16:424–455.CrossRefPubMedGoogle Scholar
  30. 30.
    Kumar S, Beaton K, Hughes T. The effectiveness of massage therapy for the treatment of nonspecific low back pain: a systematic review of systematic reviews. Int J Gen Med 2013;6:733–741.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Netchanok S, Wendy M, Marie C, Siobhan O. The effectiveness of Swedish massage and traditional Thai massage in treating chronic low back pain: a review of the literature. Complement Ther Clin Pract 2012;18:227–234.CrossRefPubMedGoogle Scholar
  32. 32.
    Cheng YH, Huang GC. Efficacy of massage therapy on pain and dysfunction in patients with neck pain: a systematic review and meta-analysis. Evid Based Complement Alternat Med 2014;2014:204360.PubMedPubMedCentralGoogle Scholar
  33. 33.
    Kong LJ, Zhan HS, Cheng YW, Yuan WA, Chen B, Fang M. Massage therapy for neck and shoulder pain: a systematic review and meta-analysis. Evid Based Complement Alternat Med 2013;2013:613279.PubMedPubMedCentralGoogle Scholar
  34. 34.
    van den Dolder PA, Ferreira PH, Refshauge KM. Effectiveness of soft tissue massage and exercise for the treatment of non-specific shoulder pain: a systematic review with meta-analysis. Br J Sports Med 2014;48:1216–1226.CrossRefPubMedGoogle Scholar
  35. 35.
    Chaibi A, Russell MB. Manual therapies for primary chronic headaches: a systematic review of randomized controlled trials. J Headache Pain 2014;15:67.CrossRefPubMedPubMedCentralGoogle Scholar
  36. 36.
    Yin P, Gao N, Wu J, Litscher G, Xu S. Adverse events of massage therapy in pain-related conditions: a systematic review. Evid Based Complement Alternat Med 2014;2014:480956.PubMedPubMedCentralGoogle Scholar
  37. 37.
    American Massage Therapy Association. Availabe at: https://www.amtamassage.org/index.html; Accessed July 28, 2015.Google Scholar
  38. 38.
    Mayoclinic.org. Acupuncture. Availabe at: http://www.mayoclinic.org/tests-procedures/acupuncture/basics/definition/prc-20020778; February 21, 2015. Accessed July 28, 2015.Google Scholar
  39. 39.
    NCCAOM.org. National Certification Commission for Acupuncture and Oreintal Medicine. Availabe at: http://www.nccaom.org/; 2014. Accessed July 28, 2015.Google Scholar
  40. 40.
    Chen S, Wang S, Rong P, Wang J, Qiao L, Feng X. Acupuncture for visceral pain: neural substrates and potential mechanisms. Evid Based Complement Alternat Med 2014;2014:609594.PubMedPubMedCentralGoogle Scholar
  41. 41.
    Harris RE, Zubieta JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ. Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on muopioid receptors (MORs). Neuroimage 2009;47:1077–1085.CrossRefPubMedPubMedCentralGoogle Scholar
  42. 42.
    Baeumler PI, Fleckenstein J, Takayama S, Simang M, Seki T, Irnich D. Effects of acupuncture on sensory perception: a systematic review and meta-analysis. PLoS One 2014;9:e113731.CrossRefPubMedPubMedCentralGoogle Scholar
  43. 43.
    NIH Consensus Conference. Acupuncture. JAMA 1998;280:1518–1524.CrossRefGoogle Scholar
  44. 44.
    Martin DP, Sletten CD, Williams BA, Berger IH. Improvement in fibromyalgia symptoms with acupuncture: results of a randomized controlled trial. Mayo Clin Proc 2006;81:749–757.CrossRefPubMedGoogle Scholar
  45. 45.
    Yang B, Yi G, Hong W, Bo C, Wang Z, Liu Y. Efficacy of acupuncture on fibromyalgia syndrome: a meta-analysis. J Tradit Chin Med 2014;34:381–391.CrossRefPubMedGoogle Scholar
  46. 46.
    Liu L, Skinner M, McDonough S, Mabire L, Baxter GD. Acupuncture for low back pain: an overview of systematic reviews. Evid Based Complement Alternat Med 2015;2015:328196.PubMedPubMedCentralGoogle Scholar
  47. 47.
    Kim KH, Kim TH, Lee BR, Kim JK, Son DW, Lee SW. Acupuncture for lumbar spinal stenosis: a systematic review and meta-analysis. Complement Ther Med 2013;21:535–556.CrossRefPubMedGoogle Scholar
  48. 48.
    Yuan QL, Guo TM, Liu L, Sun F, Zhang YG. Traditional Chinese medicine for neck pain and low back pain: a systematic review and meta-analysis. PLoS One 2015;10:e0117146.CrossRefPubMedPubMedCentralGoogle Scholar
  49. 49.
    Manyanga T, Froese M, Zarychanski R, Abou-Setta A, Friesen C, Tennenhouse M. Pain management with acupuncture in osteoarthritis: a systematic review and meta-analysis. BMC Complement Altern Med 2014;14:312.CrossRefPubMedPubMedCentralGoogle Scholar
  50. 50.
    Moon TW, Posadzki P, Choi TY, Park TY, Kim HJ, Lee MS. Acupuncture for treating whiplash associated disorder: a systematic review of randomised clinical trials. Evid Based Complement Alternat Med 2014;2014:870271.CrossRefPubMedPubMedCentralGoogle Scholar
  51. 51.
    Chien TJ, Liu CY, Chang YF, Fang CJ, Hsu CH. Acupuncture for treating aromatase inhibitor-related arthralgia in breast cancer: a systematic review and metaanalysis. J Altern Complement Med 2015;21:251–260.CrossRefPubMedPubMedCentralGoogle Scholar
  52. 52.
    Wong Lit Wan D, Wang Y, Xue CC, Wang LP, Liang FR, Zheng Z. Local and distant acupuncture points stimulation for chronic musculoskeletal pain: a systematic review on the comparative effects. Eur J Pain 2015;19:1232–1247.CrossRefPubMedGoogle Scholar
  53. 53.
    Zhao HJ, Tan JY, Wang T, Jin L. Auricular therapy for chronic pain management in adults: a synthesis of evidence. Complement Ther Clin Pract 2015;21:68–78.CrossRefPubMedGoogle Scholar
  54. 54.
    Yeh CH, Chiang YC, Hoffman SL, Liang Z, Klem ML, Tam WW. Efficacy of auricular therapy for pain management: a systematic review and meta-analysis. Evid Based Complement Alternat Med 2014;2014:934670.PubMedPubMedCentralGoogle Scholar
  55. 55.
    Tan JY, Molassiotis A, Wang T, Suen LK. Adverse events of auricular therapy: a systematic review. Evid Based Complement Alternat Med 2014;2014:506758.PubMedPubMedCentralGoogle Scholar
  56. 56.
    Wheway J, Agbabiaka TB, Ernst E. Patient safety incidents from acupuncture treatments: a review of reports to the National Patient Safety Agency. Int J Risk Saf Med 2012;24:163–169.PubMedGoogle Scholar
  57. 57.
    Scharf ML, Kommuri A. Delayed recognition of an uncommon cause of iatrogenic pneumothorax. J Bronchology Interv Pulmonol 2015;22:162–164.CrossRefPubMedGoogle Scholar
  58. 58.
    U.S. Food and Drug Administration. Dietary supplement health and education act of 1994. Availabe at: http://www.fda.gov/regulatoryinformation/legislation/federalfooddrugandcosmeticactfdcact/significantamendmentstothefdcact/ucm148003.htm; Updated May 20, 2009. Accessed July 28, 2015.Google Scholar
  59. 59.
    Federal Register.gov. Current good manufacturing practice in manufacturing, packaging, labeling, or holding operations for dietary supplements. Availabe at: https://www.federalregister.gov/articles/2007/06/25/07-3039/current-good-manufacturingpractice-in-manufacturing-packaging-labeling-or-holdingoperations-for; June 25, 2007. Accessed July 28, 2015.Google Scholar
  60. 60.
    Ko RJ. Adulterants in Asian patent medicines. N Engl J Med 1998;339:847.CrossRefPubMedGoogle Scholar
  61. 61.
    Dickinson A, Blatman J, El-Dash N, Franco JC. Consumer usage and reasons for using dietary supplements: report of a series of surveys. J Am Coll Nutr 2014;33:176–182.CrossRefPubMedGoogle Scholar
  62. 62.
    Chantre P, Cappelaere A, Leblan D, Guedon D, Vandermander J, Fournie B. Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177–183.CrossRefPubMedGoogle Scholar
  63. 63.
    Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res 2012;26:1719–1725.CrossRefPubMedGoogle Scholar
  64. 64.
    Nolano M, Simone DA, Wendelschafer-Crabb G, Johnson T, Hazen E, Kennedy WR. Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation. Pain 1999;81:135–145.CrossRefPubMedGoogle Scholar
  65. 65.
    Bottiglieri T. S-adenosyl-L-methionine (SAMe): from the bench to the bedside—molecular basis of a pleiotrophic molecule. Am J Clin Nutr 2002;76:1151S-1157S.Google Scholar
  66. 66.
    Lee JW, Lee WB, Kim W, Min BI, Lee H, Cho SH. Traditional herbal medicine for cancer pain: a systematic review and meta-analysis. Complement Ther Med 2015;23:265–274.CrossRefPubMedGoogle Scholar
  67. 67.
    Yanju B, Yang L, Hua B, Hou W, Shi Z, Li W. A systematic review and meta-analysis on the use of traditional Chinese medicine compound kushen injection for bone cancer pain. Support Care Cancer 2014;22:825–836.CrossRefPubMedGoogle Scholar
  68. 68.
    Oltean H, Robbins C, van Tulder MW, Berman BM, Bombardier C, Gagnier JJ. Herbal medicine for low-back pain. Cochrane Database Syst Rev 2014;12:CD004504.Google Scholar
  69. 69.
    Cameron M, Chrubasik S. Oral herbal therapies for treating osteoarthritis. Cochrane Database Syst Rev 2014;5:CD002947.Google Scholar
  70. 70.
    Cameron M, Chrubasik S. Topical herbal therapies for treating osteoarthritis. Cochrane Database Syst Rev 2013;5:CD010538.Google Scholar
  71. 71.
    Chen W, Zhang Y, Li X, Yang G, Liu JP. Chinese herbal medicine for diabetic peripheral neuropathy. Cochrane Database Syst Rev 2013;10:CD007796.Google Scholar
  72. 72.
    Vanherweghem JL. A new form of nephropathy secondary to the absorption of Chinese herbs. Bull Mem Acad R Med Belg 1994;149:128–135.PubMedGoogle Scholar
  73. 73.
    Yuan M, Shi YB, Li ZH, Xia, M, Ji GZ, Xu GX. De novo urothelial carcinoma in kidney transplant patients with endstage aristolochic acid nephropathy in China. Transplant Proc 2009;41:1619–1623.CrossRefPubMedGoogle Scholar
  74. 74.
    Lee WJ, Kim HW, Lee HY, Son CG. Systematic review on herb-induced liver injury in Korea. Food Chem Toxicol 2015.Google Scholar
  75. 75.
    Abdualmjid RJ, Sergi C. Hepatotoxic botanicals—an evidencebased systematic review. J Pharm Pharm Sci 2013;16:376–404.CrossRefPubMedGoogle Scholar
  76. 76.
    Johnson AC, Greenwood-Van Meerveld B. Stress-induced pain: a target for the development of novel therapeutics. J Pharmacol Exp Ther 2014;351:327–335.CrossRefPubMedPubMedCentralGoogle Scholar
  77. 77.
    Schmid J, Theysohn N, Gass F, Benson S, Gramsch C, Forsting M. Neural mechanisms mediating positive and negative treatment expectations in visceral pain: a functional magnetic resonance imaging study on placebo and nocebo effects in healthy volunteers. Pain 2013;154:2372–2380.CrossRefPubMedGoogle Scholar
  78. 78.
    Kirkpatrick DR, McEntire DM, Hambsch ZJ, Kerfeld MJ, Smith TA, Reisbig MD. Therapeutic basis of clinical pain modulation. Clin Transl Sci 2015;8:848–856.CrossRefPubMedGoogle Scholar
  79. 79.
    Hassett AL, Clauw DJ. Does psychological stress cause chronic pain? Psychiatr Clin North Am 2011;34:579–594.CrossRefPubMedGoogle Scholar
  80. 80.
    Radley JJ, Anderson RM, Hamilton BA, Alcock JA, Romig-Martin SA. Chronic stress-induced alterations of dendritic spine subtypes predict functional decrements in an hypothalamo-pituitary-adrenal-inhibitory prefrontal circuit. J Neurosci 2013;33:14379–14391.CrossRefPubMedPubMedCentralGoogle Scholar
  81. 81.
    Fox KC, Nijeboer S, Dixon ML, Floman JL, Ellamil M, Rumak SP. Is meditation associated with altered brain structure? A systematic review and meta-analysis of morphometric neuroimaging in meditation practitioners. Neurosci Biobehav Rev 2014;43:48–73.CrossRefPubMedGoogle Scholar
  82. 82.
    Nakata H, Sakamoto K, Kakigi R. Meditation reduces painrelated neural activity in the anterior cingulate cortex, insula, secondary somatosensory cortex, and thalamus. Front Psychol 2014;5:1489.CrossRefPubMedPubMedCentralGoogle Scholar
  83. 83.
    Zeidan F, Grant JA, Brown CA, McHaffie JG, Coghill RC. Mindfulness meditation-related pain relief: evidence for unique brain mechanisms in the regulation of pain. Neurosci Lett 2012;520:165–173.CrossRefPubMedPubMedCentralGoogle Scholar
  84. 84.
    Holtzman S, Beggs RT. Yoga for chronic low back pain: a meta-analysis of randomized controlled trials. Pain Res Manag 2013;18:267–272.CrossRefPubMedPubMedCentralGoogle Scholar
  85. 85.
    Cramer H, Lauche R, Haller H, Dobos G. A systematic review and meta-analysis of yoga for low back pain. Clin J Pain 2013;29:450–460.CrossRefPubMedGoogle Scholar
  86. 86.
    Lee C, Crawford C, Schoomaker E. Movement therapies for the self-management of chronic pain symptoms. Pain Med 2014;15 Suppl 1:S40–S53.CrossRefPubMedGoogle Scholar
  87. 87.
    Lee C, Crawford C, Hickey A. Mind-body therapies for the self-management of chronic pain symptoms. Pain Med 2014;15 Suppl 1:S21–S39.CrossRefPubMedGoogle Scholar
  88. 88.
    Bawa FL, Mercer SW, Atherton RJ, Clague F, Keen A, Scott NW. Does mindfulness improve outcomes in patients with chronic pain? Systematic review and meta-analysis. Br J Gen Pract 2015;65:e387–400.CrossRefPubMedPubMedCentralGoogle Scholar
  89. 89.
    Kapitza KP, Passie T, Bernateck M, Karst M. First noncontingent respiratory biofeedback placebo versus contingent biofeedback in patients with chronic low back pain: a randomized, controlled, double-blind trial. Appl Psychophysiol Biofeedback 2010;35:207–217.CrossRefPubMedGoogle Scholar
  90. 90.
    Scharff L, Marcus DA, Masek BJ. A controlled study of minimal-contact thermal biofeedback treatment in children with migraine. J Pediatr Psychol 2002;27:109–119.CrossRefPubMedGoogle Scholar
  91. 91.
    Madsen MV, Gotzsche PC, Hrobjartsson A. Acupuncture treatment for pain: systematic review of randomised clinical trials with acupuncture, placebo acupuncture, and no acupuncture groups. BMJ 2009;338:a3115.CrossRefPubMedPubMedCentralGoogle Scholar
  92. 92.
    Hall KT, Loscalzo J, Kaptchuk TJ. Genetics and the placebo effect: the placebome. Trends Mol Med 2015;21:285–294.CrossRefPubMedPubMedCentralGoogle Scholar
  93. 93.
    Kaptchuk TJ, Miller FG. Placebo effects in medicine. N Engl J Med 2015;373:8–9.CrossRefPubMedGoogle Scholar

Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Brent A. Bauer
    • 1
    Email author
  • Jon C. Tilburt
    • 1
  • Amit Sood
    • 1
  • Guang-xi Li (李光熙)
    • 2
    • 3
  • Shi-han Wang (王师菡)
    • 3
    • 4
  1. 1.Division of Complementary and Integrative MedicineMayo ClinicRochesterUSA
  2. 2.Division of Pulmonary and Critical Care MedicineMayo ClinicRochesterUSA
  3. 3.Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina
  4. 4.Division of Cardiovascular DiseasesMayo ClinicRochesterUSA

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