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Effect of Shenzhu Guanxin Recipe (参术冠心方) on patients with angina pectoris after percutaneous coronary intervention: A prospective, randomized controlled trial

Chinese Journal of Integrative Medicine volume 21, pages 408–416 (2015)Cite this article

Abstract

Objective

To evaluate the efficacy and safety of a combination therapy using Chinese medicine (CM) Shenzhu Guanxin Recipe (参术冠心方, SGR) and standard Western medicine treatment (SWMT) in patients with angina pectoris after percutaneous coronary intervention (PCI).

Methods

Double-blind randomized controlled trial was used in this experimental procedure. One hundred and eighty-seven patients with coronary heart disease receiving SWMT after PCI were randomly assigned to the treatment (SGR) and control (placebo) groups. Outcome measures including angina pectoris score (APS), CM symptom score, and Seattle Angina Questionnaire (SAQ) score were evaluated in 1, 2, 3 and 12 months, and the death rate, restenosis and other emergency treatments were observed. The mixed-effects models were employed for the data analysis.

Results

In the treatment group, a larger within-treatment effect size (d=1.74) was found, with a 76.7% reduction in APS from pretreatment to 12-month follow-up assessment compared with the control group (d=0.83, 53.8% symptom reduction); betweentreatment (BT) effect size was d=0.66. CM symptom scores included an 18.3% reduction in the treatment group (d=0.46), and a 16.1% decrease in the control group (d=0.31); d=0.62 for BT effect size. In regard to scores of SAQ, the BT effect size of cognition level of disease was larger in the treatment group (d=0.63), followed by the level of body limitation of activity (d=0.62), condition of angina pectoris attacks (d=0.55), satisfaction level of treatments (d=0.31), and steady state of angina pectoris (d=0.30). Two cardiovascular related deaths and one incidental death were recorded in the control and treatment groups, respectively. No significant difference in any cardiovascular event (including death toll, frequency of cardiovascular hospitalization or emergency room visits) was found between the two groups.

Conclusion

The combination therapy of SGR and SWMT is effective and safe in patients with angina pectoris after PCI when compared with SWMT alone.

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Author information

Affiliations

  1. Cardiovascular Department, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, China

    Dan-ping Xu, Huan-lin Wu, Tao-hua Lan & Xiao-gang Sheng

  2. Postdoctoral Mobile Research Station, Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510006, China

    Tao-hua Lan

  3. Cardiovascular Department of Ershadao Hospital, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510105, China

    Xia Wang

  4. Cardiac Surgeon Department of University Town Hospital, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510006, China

    Yu Lin

  5. Cardiovascular Department of Fangcun Hospital, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510370, China

    Song Li

  6. Cardiovascular Department of University Town Hospital, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510006, China

    Chao-yang Zheng

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  1. Dan-ping Xu
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  2. Huan-lin Wu
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  3. Tao-hua Lan
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  4. Xia Wang
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  5. Xiao-gang Sheng
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  6. Yu Lin
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  7. Song Li
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Correspondence to Huan-lin Wu.

Additional information

Supported by the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (No. 2001BAI10B02) and Science and Technology Planning Project of Guangdong Province, China (No. 2012A032500017)

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Xu, Dp., Wu, Hl., Lan, Th. et al. Effect of Shenzhu Guanxin Recipe (参术冠心方) on patients with angina pectoris after percutaneous coronary intervention: A prospective, randomized controlled trial. Chin. J. Integr. Med. 21, 408–416 (2015). https://doi.org/10.1007/s11655-015-2040-6

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Keywords

  • Shenzhu Guanxin Recipe
  • angina pectoris
  • percutaneous coronary intervention
  • coronary heart disease
  • randomized controlled trial
  • Chinese medicine