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Chinese Journal of Integrative Medicine

, Volume 21, Issue 4, pp 274–285 | Cite as

Phytochemical profiling and bioactivity of a mangrove plant, Sonneratia apetala, from Odisha Coast of India

  • Jayanta Kumar Patra
  • Swagat Kumar Das
  • Hrudayanath ThatoiEmail author
Original Article

Abstract

Objective

To test the antioxidant, antidiabetic, anticancer and antibacterial activities along with phytochemicals of Sonneratia apetala Buch.-Ham.

Methods

The antibacterial activity was determined by agar well diffusion method. The antioxidant activity was determined by standard assay. The antidiabetic activity was evaluated by α-glucosidase inhibition assay and in vivo anticancer property was determined against Ehrlich ascites carcinoma (EAC) cells in Swiss Albino mice. Further partial characterization of the methanol extracts was carried out by thin layer chromatography, high performance liquid chromatography, 1H nuclear magnetic resonance spectroscopy and Fourier transform-infra red spectrum spectral analysis.

Results

Four solvent extracts (acetone, ethanol, methanol and aqueous) of leaf and bark possess strong antioxidant properties. In vivo anticancer activity of methanol extract leaf indicated positive activity showing 34% inhibition against EAC cells in Swiss Albino mice. All extracts exhibited α-glucosidase inhibitory activity in a dose-dependent manner indicating presence of promising antidiabetic properties. The extracts possess strong antibacterial activity against the selected pathogenic bacteria (minimal inhibitory concentration ranging from 1.25–5.00 mg/mL). The partial characterization of the methanol extracts of leaf and bark revealed the presence of phenolics as the lead compound responsible for studied bioactivities of the plant extracts.

Conclusion

Sonneratia apetala extracts have potent antibacterial, antioxidant, antidiabetic and anticancer properties which can be further exploited for its pharmaceutical applications.

Keywords

bioactive compounds chromatography Ehrlich ascites carcinoma mangrove Sonneratia apetala 

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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Jayanta Kumar Patra
    • 1
    • 2
  • Swagat Kumar Das
    • 1
  • Hrudayanath Thatoi
    • 1
    Email author
  1. 1.Department of Biotechnology, College of Engineering and TechnologyBiju Patnaik University of TechnologyBhubaneswarIndia
  2. 2.School of BiotechnologyYeungnam UniversityGyeongsan, GyeongbukRepublic of Korea

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