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Cost-effectiveness analysis of combined Chinese medicine and Western medicine for ischemic stroke patients

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Abstract

Objective

To evaluate the cost-effectiveness of combining Chinese medicine (CM) with Western medicine (WM) for ischemic stroke patients.

Methods

Hospitalization summary reports between 2006 and 2010 from eight hospitals in Beijing were used to analyze the length of stay (LOS), cost per stay (CPS), and outcomes at discharge.

Results

Among 12,009 patients (female, 36.44%; mean age, 69.98±13.06 years old), a substantial number of patients were treated by the WM_Chinese patent medicine (CPM)_Chinese herbal medicine (CHM) (38.90%); followed by the WM_CPM (32.55%), the WM (24.26%), and the WM_CHM (4.15%). With adjustment for confounding variables, LOS of the WM_CPM_CHM group was about 10 days longer than that of the WM group, and about 6 days longer than that of the WM_CPM group or the WM_CHM group (P<0.01); CPS of the WM_CPM_CHM group was United States dollar (USD) 1,288 more than that of the WM group, and about USD 600 more than that of the WM_CPM group or the WM_CHM group (P<0.01). Compared with the WM group, odd ratio (OR) of recovered and improved outcome of the WM_CPM_CHM group was the highest [OR: 12.76, 95% confidence intervals (CI): 9.23, 17.64, P<0.01], OR of death outcome of the WM_CPM_CHM group was the lowest (OR: 0.08, 95% CI: 0.05, 0.12, P<0.01). There was no significant difference between LOS, CPS and OR of the WM_CPM group and those of the WM_CHM group (P>0.05). Cost/effectiveness and incremental cost-effectiveness ratio of the WM_CPM_CHM group were robustly higher than those of the WM group.

Conclusion

Compared with WM alone, supplementing CPM and CHM to WM provides significant health benefits of improving the chance of recovered and improved outcome, and reducing the death rate, at an expense of longer LOS and higher CPS.

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References

  1. Bonita R, Mendis S, Truelsen T, Bogousslavsky J, Toole J, Yatsu F. The global stroke initiative. Lancet Neurol 2004;3:391–393.

    Article  PubMed  Google Scholar 

  2. Feigin VL. Stroke epidemiology in the developing world. Lancet 2005;365:2160–2161.

    Article  PubMed  Google Scholar 

  3. Ministry of Health of the People’s Republic of China. China’s health statistics yearbook, 2011. Beijing: Peking Union Medical College Press; 2011:290,329.

    Google Scholar 

  4. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics—2012 update: a report from the American Heart Association. Circulation 2012; 125:e2–e220.

    Article  PubMed  Google Scholar 

  5. Adams HP Jr, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Circulation 2007;115:478–534.

    Article  Google Scholar 

  6. Chinese Medical Association Neuropathy Credits. Acute ischemic stroke diagnosis and treatment guildelines in China. Chin J Neurol (Chin) 2010;43:146–153.

    Google Scholar 

  7. European Stroke Organisation. Guidelines for stroke management (2008). Available at http://www.eso-stroke.org/recommendations.php. Accessed on June 1, 2012.

    Google Scholar 

  8. Hankey GJ. Neuroprotection for acute ischemic stroke: hope reignited. Lancet Neurol 2006;5:287–288.

    Article  PubMed  Google Scholar 

  9. Lapchak PA, Araujo DM. Advances in ischemic stroke treatment: neuroprotective and combination therapies. Expert Opin Emerg Drugs 2007;12:97–112.

    Article  CAS  PubMed  Google Scholar 

  10. Dirnagl U. The bad begins and worse remains behind: systemic effects of stroke as target for brain protection. Int J Stroke 2010;5:48.

    Article  Google Scholar 

  11. Shi FL, Hart RG, Sherman DG, Tegeler CH. Stroke in the People’s Republic of China. Stroke 1989;20:1581–1585.

    Article  CAS  PubMed  Google Scholar 

  12. Jiang M, Yang J, Zhang C, Liu B, Chan K, Cao HX, et al. Clinical studies with traditional Chinese medicine in the past decade and future research and development. Planta Med 2010;76:2048–2064.

    Article  CAS  PubMed  Google Scholar 

  13. Liu M, Wu B, Wang WZ, Lee LM, Zhang SH, Kong LZ. Stroke in China: epidemiology, prevention, and management strategies. Lancet Neurol 2007;6:456–464.

    Article  PubMed  Google Scholar 

  14. Wang NL, Liou YL, Lin MT, Lin CL, Chang CK. Chinese herbal medicine, Shengmai San, is effective for improving circulatory shock and oxidative damage in the brain during heatstroke. J Pharmacol Sci 2005;97:253–265.

    Article  CAS  PubMed  Google Scholar 

  15. Wu B, Liu M, Liu H, Li W, Tan S, Zhang S, et al. Metaanalysis of traditional Chinese patent medicine for ischemic stroke. Stroke 2007;38:1973–1979.

    Article  PubMed  Google Scholar 

  16. Cheng H. Scientific and cost-effect analysis of free fried pieces of Chinese medicine formulations. Capit Med (Chin) 2000;7:29–31.

    Google Scholar 

  17. Feigin VL. Herbal medicine in stroke: does it have a future? Stroke 2007;38:1734–1736.

    Article  PubMed  Google Scholar 

  18. Fønnebø V, Grimsgaard S, Walach H, Ritenbaugh C, Norheim AJ, MacPherson H, et al. Researching complementary and alternative treatments—the gatekeepers are not at home. BMC Med Res Methodol 2007;7:7.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Li AJ, Chen X. People’s doubt on traditional Chinese medicine granules. Capit Med (Chin) 2010;1:28–29.

    Google Scholar 

  20. Quintard H, Borsotto M, Veyssiere J, Gandin C, Labbal F, Widmann C, et al. MLC901, a traditional Chinese medicine protects the brain against global ischemia. Neuropharmacology 2011;61:622–631.

    Article  CAS  PubMed  Google Scholar 

  21. Tang JL, Leung PC. An efficacy-driven approach to the research and development of traditional Chinese medicine. Hongkong Med J 2001;7:375–380.

    CAS  Google Scholar 

  22. Chang YP, Xie YM. Overview of pharmacoeconomic studies on traditional Chinese medicines and Western medicines in treatment of stroke. China J Chin Mater Med (Chin) 2012;37:3509–3512.

    Google Scholar 

  23. Rao ML. China guideline for cerebrovascular disease prevention and treatment. Beijing: People’s Medical Publishing House; 2007:46–47.

    Google Scholar 

  24. Zhu HF, Newcommon NN, Cooper ME, Green TL, Seal B, Klein G, et al. Impact of a stroke unit on length of hospital stay and in-hospital case fatality. Stroke 2009;40:18–23.

    Article  PubMed  Google Scholar 

  25. Somerford PJ, Lee AH, Yau KK. Ischemic stroke hospital stay and discharge destination. Ann Epidemiol 2004;14:773–777.

    Article  PubMed  Google Scholar 

  26. Palnum KD, Andersen G, Ingeman A, Krog BR, Bartels P, Johnsen SP. Sex-related differences in quality of care and short-term mortality among patients with acute stroke in Denmark: a nationwide follow-up study. Stroke 2009;40:1134–1139.

    Article  PubMed  Google Scholar 

  27. George MG, Tong X, Kuklina EV, Labarthe DR. Trends in stroke hospitalizations and associated risk factors among children and young adults, 1995–2008. Ann Neurol 2011;70:713–721.

    Article  CAS  PubMed  Google Scholar 

  28. Tao ZR. Reliability, validity and sensitivity of Chinese scale for clinical neurological deficit of stroke patients. Acad J Second Milit Med Univ (Chin) 2009;30:283–285.

    Article  Google Scholar 

  29. Goldstein LB, Samsa GP, Matchar DB, Horner RD. Charlson index comorbidity adjustment for ischemic stroke outcome studies. Stroke 2004;35:1941–1945.

    Article  PubMed  Google Scholar 

  30. Tirschwell DL, Kukull WA, Longstreth WT. Medical complications of ischemic stroke and length of hospital stay: experience in Seattle, Washington. J Stroke Cerebrovasc Dis 1999;8:336–343.

    Article  CAS  PubMed  Google Scholar 

  31. Arnold RJG. Pharmacoeconomics: from theory to practice. Boca Raton, FL: CRC Press; 2010:163–173.

    Google Scholar 

  32. Liu MY, Chen KJ. Convergence: the tradition and the modern. Chin J Integr Med 2012;18:164–165.

    Article  PubMed  Google Scholar 

  33. Wang XJ, Sun H, Zhang AH, Sun WJ, Wang P, Wang ZG. Potential role of metabolomics approaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine. J Pharm Biomed Anal 2011;55:859–868.

    Article  CAS  PubMed  Google Scholar 

  34. Yang YH. Application principles of Chinese patent medicines and analysis of irrational drug use. Clin Med J (Chin) 2009;7:36–38.

    Google Scholar 

  35. Liu SL, Liu MF, Zhu BL. Study Progress on Chinese herbal medicine components with activity against ischemic stroke. Med Recapitul (Chin) 2009;15:3478–3480.

    Google Scholar 

  36. Tsang I, Huang S, Koehler B. Integration of Chinese medicine and Western medicine in clinical practice (patient care): past, present, and a proposed model for the future. Chin J Integr Med 2013;19:83–85.

    Article  PubMed  Google Scholar 

  37. Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, et al. The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006;313:1929–1935.

    Article  CAS  PubMed  Google Scholar 

  38. Zimmermann GR, Lehár J, Keith CT. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today 2007;12:34–42.

    Article  CAS  PubMed  Google Scholar 

  39. Diringer MN, Edwards DF, Mattson DT, Akins PT, Sheedy CW, Hsu CY, et al. Predictors of acute hospital costs for treatment of ischemic stroke in an academic center. Stroke 1999;30:724–728.

    Article  CAS  PubMed  Google Scholar 

  40. Gillum LA, Johnston SC. Characteristics of academic medical centers and ischemic stroke outcomes. Stroke 2001;32:2137–2142.

    Article  CAS  PubMed  Google Scholar 

  41. Holloway RG, Witter DM Jr, Lawton KB, Lipscomb J, Samsa G. Inpatient costs of specific cerebrovascular events at five academic medical centers. Neurology 1996;46:854–860.

    Article  CAS  PubMed  Google Scholar 

  42. He J, Kwon Y, Li C, Zhang XQ, Zhao JG. Several considerations in using traditional Chinese patent medicine for cerebral infarction. Chin J Integr Med 2012;18:571–574.

    Article  PubMed  Google Scholar 

  43. Patsopoulos NA. A pragmatic view on pragmatic trials. Dialogues Clin Neurosci 2011;13:217–224.

    PubMed Central  PubMed  Google Scholar 

  44. Lu AP, Chen KJ. Integrative medicine in clinical practice: from pattern differentiation in traditional Chinese medicine to disease treatment. Chin J Integr Med 2009;15:152.

    Article  PubMed  Google Scholar 

  45. Lu AP, Bian ZX, Chen KJ. Bridging the traditional Chinese medicine pattern classification and biomedical disease diagnosis with systems biology. Chin J Integr Med 2012;18:883–890.

    Article  PubMed  Google Scholar 

Download references

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Correspondence to Lue-ping Zhao  (赵乐平).

Additional information

Partly supported by the “985” Project from Ministry of Education of China (No. BMU20100107)

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Li, Y., Xi, Hx., Zhu, S. et al. Cost-effectiveness analysis of combined Chinese medicine and Western medicine for ischemic stroke patients. Chin. J. Integr. Med. 20, 570–584 (2014). https://doi.org/10.1007/s11655-014-1759-9

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  • DOI: https://doi.org/10.1007/s11655-014-1759-9

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