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Chinese Journal of Integrative Medicine

, Volume 21, Issue 4, pp 312–320 | Cite as

Songling Xuemaikang Capsule (松龄血脉康胶囊) for primary hypertension: A systematic review of randomized controlled trials

  • Xiao-chen Yang (杨晓忱)
  • Xing-jiang Xiong (熊兴江)
  • Guo-yan Yang (杨国彦)
  • He-ran Wang (王贺冉)
  • Jie Wang (王 阶)Email author
Evidence-Based Integrative Medicine

Abstract

Objective

To evaluate the effectiveness and safety of Songling Xuemaikang Capsule (松龄血脉康胶囊, SXC) for the treatment of primary hypertension.

Methods

An extensive search including Cochrane Library, PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), KoreaMed, Japanese database, and online clinical trial registry websites was performed up to February 2013. Randomized controlled trials (RCTs) regarding SXC for the treatment of primary hypertension were searched without no language restrictions. The quality of each trial was assessed according to the Cochrane Reviewers’ Handbook 5.0, and RevMan 5.0 provided by the Cochrane Collaboration.

Result

A total of 17 RCTs involving 1,778 patients were included. Meta-analysis showed that there was no significant difference between SXC and antihypertensive agents on systolic blood pressure [mean difference (MD): −0.10 [−4.83, 4.63]; P=0.97] and diastolic blood pressure (MD: 1.00 [−1.16, 3.16]; P=0.36), but SXC combined with antihypertensive drugs was more effective in lowering systolic blood pressure (MD: −6.17 [−7.86, −4.49]; P<0.00001) and diastolic blood pressure (MD: −7.24 [−8.62, −5.85]; P<0.00001) compared with the antihypertensive drugs alone.

Conclusions

SXC used alone or combined with antihypertensive drugs appear to be an effective treatment for lowering elevated blood pressure and improving symptoms in patients with primary hypertension. However, the conclusion cannot be drawn definitely due to the poor quality of the included studies. There is still an urgent need for well-designed, long-term studies to address the benefits of SXC for treating primary hypertension.

Keywords

Songling Xuemaikang Capsule primary hypertension Chinese patent medicine systematic review randomized controlled trials 

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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Xiao-chen Yang (杨晓忱)
    • 1
  • Xing-jiang Xiong (熊兴江)
    • 1
  • Guo-yan Yang (杨国彦)
    • 2
  • He-ran Wang (王贺冉)
    • 3
  • Jie Wang (王 阶)
    • 1
    Email author
  1. 1.Department of Cardiology, Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina
  2. 2.Centre for Evidence-Based Chinese MedicineBeijing University of Chinese MedicineBeijingChina
  3. 3.Cancer Research InstituteCentral South UniversityChangshaChina

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