Chinese Journal of Integrative Medicine

, Volume 22, Issue 10, pp 759–767 | Cite as

Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration

  • Kah-Hui WongEmail author
  • Gowri Kanagasabapathy
  • Murali Naidu
  • Pamela David
  • Vikineswary Sabaratnam
Original Article



To study the ability of aqueous extract of Hericium erinaceus mushroom in the treatment of nerve injury following peroneal nerve crush in Sprague-Dawley rats.


Aqueous extract of Hericium erinaceus was given by daily oral administration following peroneal nerve crush injury in Sprague-Dawley rats. The expression of protein kinase B (Akt) and mitogen-activated protein kinase (MAPK) signaling pathways; and c-Jun and c-Fos genes were studied in dorsal root ganglia (DRG) whereas the activity of protein synthesis was assessed in peroneal nerves by immunohistochemical method.


Peripheral nerve injury leads to changes at the axonal site of injury and remotely located DRG containing cell bodies of sensory afferent neurons. Immunofluorescence studies showed that DRG neurons ipsilateral to the crush injury in rats of treated groups expressed higher immunoreactivities for Akt, MAPK, c-Jun and c-Fos as compared with negative control group (P <0.05). The intensity of nuclear ribonucleoprotein in the distal segments of crushed nerves of treated groups was significantly higher than in the negative control group (P <0.05).


H. erinaceus is capable of promoting peripheral nerve regeneration after injury. Potential signaling pathways include Akt, MAPK, c-Jun, and c-Fos, and protein synthesis have been shown to be involved in its action.


Hericium erinaceus dorsal root ganglia signaling pathways gene expression protein synthesis machinery peripheral nerve regeneration 


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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Kah-Hui Wong
    • 1
    • 2
    Email author
  • Gowri Kanagasabapathy
    • 2
  • Murali Naidu
    • 1
    • 2
  • Pamela David
    • 1
    • 2
  • Vikineswary Sabaratnam
    • 2
    • 3
  1. 1.Department of Anatomy, Faculty of MedicineUniversity of MalayaKuala LumpurMalaysia
  2. 2.Mushroom Research CentreUniversity of MalayaKuala LumpurMalaysia
  3. 3.Institute of Biological Sciences, Faculty of ScienceUniversity of MalayaKuala LumpurMalaysia

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